Lanzinger, Stefanie; Karges, Wolfram; Merger, Sigrun; Laimer, Markus; Lück, Ursula; Wagner, Christian; Milek, Karsten; Holl, Reinhard W. (2020). Comparing diabetes due to diseases of the exocrine pancreas to type 1 and type 2 diabetes using propensity score matching. Pancreatology, 20(5), pp. 860-866. Elsevier 10.1016/j.pan.2020.05.023
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Objective: To estimate the prevalence of diabetes due to diseases of the exocrine pancreas (DEP) using data of the multicentre diabetes patient follow-up registry. Moreover, we aimed at comparing individuals with diabetes due to DEP to individuals with type 1 and type 2 diabetes.
Methods: Individuals with DEP, type 1 or type 2 diabetes ≥18 years of age were studied. We aggregated the most recent treatment year per patient and used propensity scores to match diabetes due to DEP to type 1 and type 2 diabetes. Matching was conducted one-to-one with sex, age, diabetes duration, migration background and the German index of socioeconomic deprivation as covariates.
Results: We identified 7,093 (1.6%) individuals with diabetes due to DEP. In the matched cohort DEP-type 1 diabetes we observed a similar daily insulin dose (0.62 IU/kg (95% confidence interval:0.60-0.63), 0.60 IU/kg (0.58-0.62)) and significant differences regarding microvascular (41.0% (39.7-42.2), 45.3% (44.0-46.6)), and macrovascular disease (16.6% (15.7-17.6), 14.7% (13.8-15.6)). HbA1c (8.2% (8.1-8.3), 7.9% (7.8-8.0)), daily insulin dose (0.60 IU/kg (0.58-0.62), 0.56 IU/kg (0.54-0.58)) and event rates of severe hypoglycemia (23.9 events/100 PY (21.4-26.8), (9.5 events/100 PY (8.0-11.2)) were significantly higher in individuals with diabetes due to DEP compared to type 2 diabetes.
Conclusions: Using registry data, rare diabetes types such as diabetes due to DEP can be studied with a significant sample size. Our study identified differences and similarities between adult individuals with DEP related diabetes and type 1 or type 2 diabetes.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Laimer, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1424-3903 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Laura Cavalli |
Date Deposited: |
24 Jan 2022 15:39 |
Last Modified: |
05 Dec 2022 16:01 |
Publisher DOI: |
10.1016/j.pan.2020.05.023 |
PubMed ID: |
32620406 |
BORIS DOI: |
10.48350/163796 |
URI: |
https://boris.unibe.ch/id/eprint/163796 |
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