Impact of menopausal hormone therapy on colorectal cancer risk-A systematic review.

Nakhostin, Livia; Stadler, Aurelia; Stute, Petra (2021). Impact of menopausal hormone therapy on colorectal cancer risk-A systematic review. Clinical endocrinology, 95(3), pp. 390-397. Wiley 10.1111/cen.14469

Text Clinical_Endocrinology_-_2021_-_Nakhostin_-_Impact_of_menopausal_hormone_therapy_on_colorectal_cancer_risk_A_systematic.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (298kB) | Request a copy

Colorectal cancer (CRC) is the second most frequently diagnosed cancer in females worldwide. Menopausal hormone therapy (MHT) has been proposed as a potential protective factor for the development of CRC. Yet, the available evidence is controversial. Thus, we aimed at summarizing the current evidence on the effect of MHT on CRC through a systematic review. A systematic literature search identified 1001 potentially relevant articles, out of which 57 original studies and nine meta-analyses were deemed eligible for the final synthesis. The evidence synthesis showed the following: (1) MHT showed a heterogeneity in findings for CRC risk with a slight tendency to a neutral or protective effect; (2) MHT effect was either neutral or protective on colorectal adenoma; (3) MHT had no impact on tumour grade, subsite and histologic types; (4) MHT was not associated with CRC mortality; and (5) MHT showed heterogeneous effects on CRC stage and invasiveness, respectively. In summary, despite some evidence pointing towards a protective effect of MHT on CRC, MHT is currently not recommended for primary CRC prevention by international guidelines due to several important, potentially harmful effects.

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