Clinical Parameters and Oral Fluid Biomarkers in Gingivitis Subjects using an Electric Toothbrush with Irrigator vs a Manual Toothbrush Alone over 8 Weeks: A Randomised Controlled Clinical Trial.

Ramseier, Christoph A; Petitat, Chloé; Trepp, Sidonia; Lang, Niklaus P; Eick, Sigrun; Adam, Ralf; Ccahuana-Vasquez, Renzo A; Barker, Matthew L; Timm, Hans; Klukowska, Malgorzata; Salvi, Giovanni E (2021). Clinical Parameters and Oral Fluid Biomarkers in Gingivitis Subjects using an Electric Toothbrush with Irrigator vs a Manual Toothbrush Alone over 8 Weeks: A Randomised Controlled Clinical Trial. Oral health & preventive dentistry, 19(1), pp. 137-147. Quintessence 10.3290/j.ohpd.b966767

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PURPOSE

To compare clinical outcomes and oral fluid biomarkers in gingivitis subjects using an electric toothbrush/irrigator combination (test) or a manual toothbrush alone (control) over 8 weeks.

MATERIALS AND METHODS

Subjects were randomly assigned to two groups of n = 30. In both groups, toothbrushing was performed twice daily at home and no additional interdental cleaning aids were allowed. Plaque Index (PLI), Gingival Index (GI), whole saliva (WS), and gingival crevicular fluid (GCF) samples were collected at weeks 2, 4, and 8.

RESULTS

Subjects' mean age was 23 years and 52% were female. Overall baseline means were 1.31 for PLI, 1.07 for GI, and 34.9 for number of bleeding sites. At every follow-up visit, both groups differed statistically significantly (p < 0.001) from baseline for all clinical parameters. The test group demonstrated statistically significantly (p < 0.001) greater reductions in GI vs the control group by 18% at week 2, 17% at week 4 and 24% at week 8. The test group also demonstrated statistically significantly (p < 0.002) greater reductions in the number of bleeding sites vs the control group by 33% at week 2, 34% at week 4 and 43% at week 8. Between-group comparisons for both WS and GCF revealed numerical trends for decreased levels of interleukin (IL)-1β in GCF after 4 and 8 weeks, but these were not statistically significant.

CONCLUSION

In subjects using the electric toothbrush/irrigator combination, increased clinical improvements may be found accompanied by similarly improved trends for oral fluid biomarkers such as IL-1β.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > Periodontics Research

UniBE Contributor:

Ramseier, Christoph Andreas; Lang, Niklaus Peter; Eick, Sigrun and Salvi, Giovanni Edoardo

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1757-9996

Publisher:

Quintessence

Language:

English

Submitter:

Doris Burri

Date Deposited:

28 Jan 2022 12:28

Last Modified:

28 Jan 2022 12:31

Publisher DOI:

10.3290/j.ohpd.b966767

PubMed ID:

33615769

Uncontrolled Keywords:

gingival crevicular fluid gingivitis prevention toothbrushing

BORIS DOI:

10.48350/163886

URI:

https://boris.unibe.ch/id/eprint/163886

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