Cognitive health after menopause: Does menopausal hormone therapy affect it?

Stute, Petra; Wienges, Johanna; Koller, Anne-Sophie; Giese, Christina; Wesemüller, Wiebke; Janka, Heidrun; Baumgartner, Sabrina (2021). Cognitive health after menopause: Does menopausal hormone therapy affect it? Best practice & research. Clinical endocrinology & metabolism, 35(6), p. 101565. Elsevier 10.1016/j.beem.2021.101565

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Dementia is a pandemic chronic non-communicable disease. 10 in 100 women above age 65 will be diagnosed with dementia, primarily Alzheimer's disease (AD). Apart from age and hereditary risk factors, there are multiple acquired risk and protective factors. So far, Menopausal Hormone Therapy (MHT) is not recommended as preventive measure. A systematic literature search on MHT and dementia risk and MHT and cognitive performance in demented women, respectively, was performed. Two recent meta-analyses identified 18 and 16 studies analyzing the impact of MHT on dementia/AD risk. Our systematic literature search identified eight additional original articles. The majority of studies found a risk reducing impact of MHT by 11-33%. However, results may vary depending on MHT type, age at initiation and study design. For example, the Women's Health Initiative Memory Study (WHIMS) reported an approximately 2-fold increased risk of dementia/Alzheimer's disease if MHT comprising conjugated equine estrogens and medroxyprogesterone acetate was initiated in predominantly comorbid postmenopausal women above age 65. In general, MHT displays a beneficial effect on several dementia risk factors and also augments some protective factors. Accordingly, clinicians can be reassured that MHT can be safely prescribed in the context of cognition in women free of dementia. However, MHT is not indicated for cognitive improvement in demented women. International scientific guidelines on MHT and dementia should consider incorporating most recent data.

Item Type:

Journal Article (Review Article)


13 Central Units > Administrative Director's Office > University Library of Bern
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Stute, Petra, Janka, Heidrun Ilonka


000 Computer science, knowledge & systems > 020 Library & information sciences
600 Technology > 610 Medicine & health








Monika Zehr

Date Deposited:

07 Jan 2022 18:42

Last Modified:

05 Dec 2022 16:01

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Alzheimer's disease counseling tool dementia menopausal hormone therapy menopause prevention




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