Leaves and Fruits Preparations of Pistacia lentiscus L.: A Review on the Ethnopharmacological Uses and Implications in Inflammation and Infection.

Milia, Egle; Bullitta, Simonetta Maria; Mastandrea, Giorgio; Szotáková, Barbora; Schoubben, Aurélie; Langhansová, Lenka; Quartu, Marina; Bortone, Antonella; Eick, Sigrun (2021). Leaves and Fruits Preparations of Pistacia lentiscus L.: A Review on the Ethnopharmacological Uses and Implications in Inflammation and Infection. Antibiotics, 10(4) MDPI 10.3390/antibiotics10040425

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There is an increasing interest in revisiting plants for drug discovery, proving scientifically their role as remedies. The aim of this review was to give an overview of the ethnopharmacological uses of Pistacia lentiscus L. (PlL) leaves and fruits, expanding the search for the scientific discovery of their chemistry, anti-inflammatory, antioxidative and antimicrobial activities. PlL is a wild-growing shrub rich in terpenoids and polyphenols, the oil and extracts of which have been widely used against inflammation and infections, and as wound healing agents. The more recurrent components in PlL essential oil (EO) are represented by α-pinene, terpinene, caryophyllene, limonene and myrcene, with high variability in concentration depending on the Mediterranean country. The anti-inflammatory activity of the oil mainly occurs due to the inhibition of pro-inflammatory cytokines and the arachidonic acid cascade. Interestingly, the capacity against COX-2 and LOX indicates PlL EO as a dual inhibitory compound. The high content of polyphenols enriching the extracts provide explanations for the known biological properties of the plant. The protective effect against reactive oxygen species is of wide interest. In particular, their anthocyanins content greatly clarifies their antioxidative capacity. Further, the antimicrobial activity of PlL oil and extracts includes the inhibition of Staphylococcus aureus, Escherichia coli, periodontal bacteria and Candida spp. In conclusion, the relevant scientific properties indicate PlL as a nutraceutical and also as a therapeutic agent against a wide range of diseases based on inflammation and infections.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > Periodontics Research

UniBE Contributor:

Eick, Sigrun

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2079-6382

Publisher:

MDPI

Language:

English

Submitter:

Doris Burri

Date Deposited:

26 Jan 2022 11:56

Last Modified:

26 Jan 2022 11:56

Publisher DOI:

10.3390/antibiotics10040425

PubMed ID:

33921406

Uncontrolled Keywords:

Mediterranean plants essential oils ethanol extracts natural anti-inflammatory natural antimicrobials pharmaceutical plants polyphenols terpenoids water extracts

BORIS DOI:

10.48350/163917

URI:

https://boris.unibe.ch/id/eprint/163917

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