Enamel matrix derivative and subgingival reinstrumentation: a pilot study.

Jentsch, Holger F R; Thomaidis, Ch Paschalis Ch; Schütz, Tino; Eick, Sigrun (2021). Enamel matrix derivative and subgingival reinstrumentation: a pilot study. Quintessence international, 52(6), pp. 506-513. Quintessenz 10.3290/j.qi.b1044079

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OBJECTIVES

To verify the effect of adjunctive enamel matrix derivative (EMD) in subgingival reinstrumentation during supportive periodontal therapy.

METHOD AND MATERIALS

Using a split-mouth design, residual periodontal pockets with probing depth (PD) of 5 to 8 mm in 13 patients were treated by subgingival reinstrumentation with (test teeth) and without (control teeth) EMD. At baseline and after 6 and 12 months the clinical variables PD, clinical attachment level (CAL), and bleeding on probing (BOP) were recorded. At the same appointments gingival crevicular fluid (GCF) was collected to analyze for interleukin (IL)-1β, matrix metalloproteinase (MMP)-8, IL-10, and transforming growth factor (TGF)-β.

RESULTS

Statistically significant improvements in PD, CAL, and BOP occurred in both groups. The reduction of PD was significantly higher in the test group than in the control group after 12 months (P = .005). The change of IL-1β within 12 months was significantly different between both groups (P = .019). No other significant differences were detected between both groups.

CONCLUSION

The study suggests that subgingival reinstrumentation with adjunctive EMD could additionally reduce probing pocket depth and the need for periodontal surgery. (Quintessence Int 2021;52:506-513; doi: 10.3290/j.qi.b1044079).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > Periodontics Research

UniBE Contributor:

Eick, Sigrun

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1936-7163

Publisher:

Quintessenz

Language:

English

Submitter:

Doris Burri

Date Deposited:

28 Jan 2022 12:59

Last Modified:

05 Dec 2022 16:01

Publisher DOI:

10.3290/j.qi.b1044079

PubMed ID:

33688713

Uncontrolled Keywords:

biomarkers clinical variables enamel matrix proteins periodontitis scaling and root planing

BORIS DOI:

10.48350/163922

URI:

https://boris.unibe.ch/id/eprint/163922

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