Koch-Heier, Julia; Hoffmann, Helen; Schindler, Michael; Lussi, Adrian; Planz, Oliver (2021). Inactivation of SARS-CoV-2 through Treatment with the Mouth Rinsing Solutions ViruProX® and BacterX® Pro. Microorganisms, 9(3) MDPI 10.3390/microorganisms9030521
|
Text
microorganisms-09-00521-v2.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic effects daily dental work. Therefore, infection control measures are necessary to prevent infection of dental personnel during dental treatments. The use of a preprocedural mouth rinse with chlorhexidine (CHX), cetylpyridinium chloride (CPC), or hydrogen peroxide (H2O2) solution for 30-60 s may reduce the viral load and may protect the personnel in a dental practice. In the present study the virucidal effect of the mouth rinsing solutions ViruProX® with 0.05% CPC and 1.5% H2O2 and BacterX® pro containing 0.1% CHX, 0.05% CPC, and 0.005% sodium fluoride (F-) was investigated in vitro. The mouth rinsing solutions successfully inactivated infectious SARS-CoV-2 particles, the causative agent of coronavirus disease 2019 (COVID-19), within 30 s. To determine the effective components, CHX, CPC, H2O2, and a combination of CHX and CPC, were tested against SARS-CoV-2 in addition. While a combination of CPC and CHX as well as CPC alone led to a significant reduction of infectious viral particles, H2O2 and CHX alone had no virucidal effect against SARS-CoV-2. It can be assumed that preprocedural rinsing of the mouth with ViruProX® or BacterX® pro will reduce the viral load in the oral cavity and could thus lower the transmission of SARS-CoV-2 in dental practice.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Research |
UniBE Contributor: |
Lussi, Adrian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2076-2607 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Doris Burri |
Date Deposited: |
31 Jan 2022 10:41 |
Last Modified: |
05 Dec 2022 16:02 |
Publisher DOI: |
10.3390/microorganisms9030521 |
PubMed ID: |
33802603 |
Uncontrolled Keywords: |
BacterX® pro SARS-CoV-2 ViruProX® cetylpyridinium chloride mouth rinsing solution |
BORIS DOI: |
10.48350/163995 |
URI: |
https://boris.unibe.ch/id/eprint/163995 |
Actions (login required)
 |
Edit item |