Melanoma of the Nail Apparatus: An Analysis of Patients' Survival and Associated Factors.

Seyed Jafari, S Morteza; Lieberherr, Sven; Cazzaniga, Simone; Beltraminelli, Helmut; Haneke, Eckart; Hunger, Robert E (2022). Melanoma of the Nail Apparatus: An Analysis of Patients' Survival and Associated Factors. Dermatology, 238(1), pp. 156-160. Karger 10.1159/000514493

Text 000514493.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (292kB) | Request a copy

BACKGROUND

There are no proper management guidelines for nail apparatus melanoma (NAM).

OBJECTIVE

This study aimed to describe the clinical features, the presence of locoregional and distant metastases and disease-free and overall survival of NAM treated at our institution.

METHODS

A retrospective cohort review of patients with single, primary localized histopathologically confirmed NAM was performed. Collected data consisted of patients' characteristics and tumor features. In addition, local recurrence, locoregional metastases, distant metastases, disease-free survival (DFS) and overall survival (OS) were used as the main outcomes in our analysis.

RESULTS

Thirty patients with NAM were included. The overall survival (OS) in our patients at 5 and 10 years was 85.6 and 73.4%, respectively. DFS was significantly higher in patients with primary tumor location in the hand and without tumor-infiltrating lymphocytes (p value = 0.01 and 0.04, respectively). The patients with in situ melanoma or Breslow thickness <1 mm had a significantly higher chance of DFS and OS (90.0 and 94.1% at 5 years, respectively) than those with thicker NAM (58.3 and 55.6% at 5 years, respectively). A total of 53.3% of 30 patients underwent primary excision and covering with a full-thickness skin graft, while 13.3% of our 30 patients underwent digit amputation. The patients who underwent excision and covering with a full-thickness skin graft showed a complete overall survival (100% at 5 years).

CONCLUSION

Primary tumor location in the hand and lower tumor thickness might be correlated with better patients' survival. The study results suggest that total amputation might not be necessary in all NAM cases.

Interest & Impact

Downloads

0 since deposited on 31 Jan 2022
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item