Aging and Chronic Liver Disease.

Maeso-Díaz, Raquel; Gracia-Sancho, Jorge (2020). Aging and Chronic Liver Disease. Seminars in liver disease, 40(4), pp. 373-384. Thieme 10.1055/s-0040-1715446

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Aging increases the incidence of chronic liver disease (CLD), worsens its prognosis, and represents the predominant risk factor for its development at all different stages. The hepatic sinusoid, which is fundamental for maintaining liver homeostasis, is composed by hepatocytes, liver sinusoidal endothelial cells, hepatic stellate cells, and hepatic macrophages. During CLD progression, hepatic cells suffer deregulations in their phenotype, which ultimately lead to disease development. The effects of aging on the hepatic sinusoid phenotype and function are not well understood, nevertheless, studies performed in experimental models of liver diseases and aging demonstrate alterations in all hepatic sinusoidal cells. This review provides an updated description of age-related changes in the hepatic sinusoid and discusses the implications for CLD development and treatment. Lastly, we propose aging as a novel therapeutic target to treat liver diseases and summarize the most promising therapies to prevent or improve CLD and extend healthspan.

Item Type:	Journal Article (Review Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
UniBE Contributor:	Gracia Sancho, Jorge Sergio
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1098-8971
Publisher:	Thieme
Language:	English
Submitter:	Rahel Fuhrer
Date Deposited:	03 Feb 2022 08:51
Last Modified:	05 Dec 2022 16:03
Publisher DOI:	10.1055/s-0040-1715446
PubMed ID:	33764489
URI:	https://boris.unibe.ch/id/eprint/164378