Raab, Anja Maria; Mueller, Gabi; Elsig, Simone; Gandevia, Simon C; Zwahlen, Marcel; Hopman, Maria T E; Hilfiker, Roger (2022). Systematic Review of Incidence Studies of Pneumonia in Persons with Spinal Cord Injury. Journal of clinical medicine, 11(1), p. 211. MDPI 10.3390/jcm11010211
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Pneumonia continues to complicate the course of spinal cord injury (SCI). Currently, clinicians and policy-makers are faced with only limited numbers of pneumonia incidence in the literature. A systematic review of the literature was undertaken to provide an objective synthesis of the evidence about the incidence of pneumonia in persons with SCI. Incidence was calculated per 100 person-days, and meta-regression was used to evaluate the influence of the clinical setting, the level of injury, the use of mechanical ventilation, the presence of tracheostomy, and dysphagia. For the meta-regression we included 19 studies. The incidence ranged from 0.03 to 7.21 patients with pneumonia per 100 days. The main finding of this review is that we found large heterogeneity in the reporting of the incidence, and we therefore should be cautious with interpreting the results. In the multivariable meta-regression, the incidence rate ratios showed very wide confidence intervals, which does not allow a clear conclusion concerning the risk of pneumonia in the different stages after a SCI. Large longitudinal studies with a standardized reporting on risk factors, pneumonia, and detailed time under observation are needed. Nevertheless, this review showed that pneumonia is still a clinically relevant complication and pneumonia prevention should focus on the ICU setting and patients with complete tetraplegia.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Zwahlen, Marcel |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
2077-0383 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Andrea Flükiger-Flückiger |
Date Deposited: |
28 Jan 2022 20:24 |
Last Modified: |
29 Dec 2022 12:36 |
Publisher DOI: |
10.3390/jcm11010211 |
PubMed ID: |
35011951 |
Uncontrolled Keywords: |
incidence pneumonia spinal cord injury systematic review |
BORIS DOI: |
10.48350/164591 |
URI: |
https://boris.unibe.ch/id/eprint/164591 |
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