Watt, Jennifer A; Del Giovane, Cinzia; Jackson, Dan; Turner, Rebecca M; Tricco, Andrea C; Mavridis, Dimitris; Straus, Sharon E; Veroniki, Areti-Angeliki (2022). Incorporating dose effects in network meta-analysis. BMJ, 376, e067003. BMJ Publishing Group 10.1136/bmj-2021-067003
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Systematic reviews with network meta-analysis that ignore potential dose effects could limit the applicability and validity of review findings. This article aims to help content experts (eg, clinicians), methodologists, and statisticians better understand how to incorporate dose effects in network meta-analysis. Three models are described that make different clinical and statistical assumptions about how to model dose effects. This article also illustrates the importance of dose effects in understanding the potential risk of harm in people with dementia from cerebrovascular events associated with atypical antipsychotic drug use (quetiapine, olanzapine, and risperidone) and the potential risk of harm in people with nausea and headache associated with cholinesterase inhibitor use (donepezil, galantamine, and rivastigmine). Finally, important considerations when choosing between different network meta-analysis models incorporating dose effects are discussed.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM) |
UniBE Contributor: |
Del Giovane, Cinzia |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1756-1833 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Andrea Flükiger-Flückiger |
Date Deposited: |
27 Jan 2022 18:14 |
Last Modified: |
05 Dec 2022 16:05 |
Publisher DOI: |
10.1136/bmj-2021-067003 |
PubMed ID: |
35042687 |
BORIS DOI: |
10.48350/164853 |
URI: |
https://boris.unibe.ch/id/eprint/164853 |
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