Wang, Bing; Deng, Hui; Hu, Yao; Han, Ling; Huang, Qiong; Fang, Xu; Yang, Ke; Wu, Siyuan; Zheng, Zhizhong; Yawalkar, Nikhil; Zhang, Zhenghua; Yan, Kexiang (2022). The difference of lipid profiles between psoriasis with arthritis and psoriasis without arthritis and sex-specific downregulation of methotrexate on the apolipoprotein B/apolipoprotein A-1 ratio. Arthritis research & therapy, 24(1), p. 17. BioMed Central 10.1186/s13075-021-02715-4
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BACKGROUND
Methotrexate (MTX) has a protective effect against cardiovascular diseases (CVD), but the mechanism is unclear.
OBJECTIVE
To investigate the effect of MTX on lipid profiles and the difference between psoriasis without arthritis (PsO) and psoriatic arthritis (PsA).
METHODS
In this prospective study, we recruited 288 psoriatic patients (136 PsA and 152 PsO) who completed 12 weeks of MTX treatment. Total cholesterol (TC), triglycerides (TG), lipoprotein A [LP(a)], high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), and ApoB were measured.
RESULTS
Compared with sex- and age-matched healthy controls, psoriatic patients had significantly (p < 0.0001) higher levels of proatherogenic lipids and lower levels of anti-atherogenic lipids. PsA patients had a higher ApoB/ApoA1 ratio than PsO patients (p < 0.05). Stepwise regression analysis found a positive correlation between the inflammatory marker hCRP and the Psoriasis Area Severity Index (PASI), ApoB/ApoA1 ratio, BMI, and smoking. ApoB was positively associated with concomitant arthritis, diabetes, and hypertension. MTX decreased the levels of pro-atherogenic and anti-atherogenic lipids. However, a significant reduction of the ApoB/ApoA1 ratio by MTX was only observed in male patients.
CONCLUSION
PsA patients had a significantly higher percentage of concomitant disease than PsO. The decrease of MTX on CVD might be related with sex.
TRIAL REGISTRATION
ChiCTR2000036192.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Yawalkar, Nikhil |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1478-6354 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Andrea Studer-Gauch |
Date Deposited: |
15 Feb 2022 14:10 |
Last Modified: |
05 Dec 2022 16:06 |
Publisher DOI: |
10.1186/s13075-021-02715-4 |
PubMed ID: |
34996506 |
Uncontrolled Keywords: |
Apolipoproteins Lipid profiles Methotrexate Psoriasis Psoriatic arthritis |
BORIS DOI: |
10.48350/164919 |
URI: |
https://boris.unibe.ch/id/eprint/164919 |
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