Involvement of autophagy in the response of tumor cells to PtdIns3K inhibitors: therapeutic implications

Arcaro, Alexandre (2013). Involvement of autophagy in the response of tumor cells to PtdIns3K inhibitors: therapeutic implications. Autophagy, 9(4), pp. 607-8. Austin, Tex.: Landes Bioscience 10.4161/auto.23461

Full text not available from this repository.

The phosphoinositide 3-kinase (PI3K) pathway plays a crucial role in cell proliferation and survival and is frequently activated by genetic and epigenetic alterations in human cancer. An arsenal of pharmacological inhibitors of key signaling enzymes in this pathway, including class I(A) PI3K isoforms, has been developed in the past decade and several compounds have entered clinical testing in cancer patients. The PIK3CA/p110α isoform is the most studied enzyme of the family and a validated cancer target. The induction of autophagy by PI3K pathway inhibitors has been documented in various cancers, although a clear picture about the significance of this phenomenon is still missing, especially in the in vivo situation. A better understanding of the contribution of autophagy to the action of PI3K inhibitors on tumors cells is important, since it may limit or enhance the action of these compounds, depending on the cellular context.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
UniBE Contributor:	Arcaro, Alexandre
ISSN:	1554-8627
Publisher:	Landes Bioscience
Language:	English
Submitter:	Anette van Dorland
Date Deposited:	04 Oct 2013 14:40
Last Modified:	05 Dec 2022 14:12
Publisher DOI:	10.4161/auto.23461
PubMed ID:	23324613
Web of Science ID:	000316732200014
URI:	https://boris.unibe.ch/id/eprint/16509 (FactScience: 224162)