Rhinovirus infections in infancy and early childhood

Kieninger, Elisabeth; Fuchs, Oliver; Latzin, Philipp; Frey, Urs; Regamey, Nicolas (2013). Rhinovirus infections in infancy and early childhood. European respiratory journal, 41(2), pp. 443-52. Sheffield, UK: European Respiratory Society 10.1183/0903193600203511

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Rhinovirus (RV) infections occur early and recurrently in life, imposing a significant burden of disease on infants and young children. They are the most frequent causative agents of both upper and lower respiratory tract infections in this age group and are associated with a broad variety of clinical outcomes, ranging from asymptomatic infections to severe respiratory disease requiring hospitalisation. In addition to their impact on short-term morbidity, RVs are also debated as important pathogens in the development of recurrent wheeze and/or asthma. Several studies in infants at high-risk for atopy and asthma and in hospitalised children have demonstrated that recurrent wheezing illnesses induced by RVs early in life are a risk factor for the development of asthma later in childhood. However, underlying mechanisms are poorly understood. The question whether RVs are directly involved in the development of childhood wheeze and asthma, or whether symptomatic RV infections only represent a proxy for infants prone to develop obstructive lung diseases, is still open. In this review we provide an overview on the role of RVs as important disease-causing agents from infancy to early childhood and discuss their contribution to the subsequent development of childhood wheeze and/or asthma.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Kieninger, Elisabeth; Fuchs, Oliver; Latzin, Philipp and Regamey, Nicolas

ISSN:

0903-1936

Publisher:

European Respiratory Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:41

Last Modified:

06 Dec 2013 13:38

Publisher DOI:

10.1183/0903193600203511

PubMed ID:

22743674

Web of Science ID:

000314624200029

URI:

https://boris.unibe.ch/id/eprint/16528 (FactScience: 224181)

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