The CD70-CD27 axis in oncology: the new kids on the block.

Flieswasser, Tal; Van den Eynde, Astrid; Van Audenaerde, Jonas; De Waele, Jorrit; Lardon, Filip; Riether, Carsten; de Haard, Hans; Smits, Evelien; Pauwels, Patrick; Jacobs, Julie (2022). The CD70-CD27 axis in oncology: the new kids on the block. Journal of experimental & clinical cancer research, 41(1), p. 12. BioMed Central 10.1186/s13046-021-02215-y

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The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within the tumor and its microenvironment is associated with tumor progression and immunosuppression. This is in contrast to physiological conditions, where tightly controlled expression of CD70 and CD27 plays a role in co-stimulation in immune responses. In hematological malignancies, cancer cells co-express CD70 and CD27 promoting stemness, proliferation and survival of malignancy. In solid tumors, only expression of CD70 is present on the tumor cells which can facilitate immune evasion through CD27 expression in the tumor microenvironment. The discovery of these tumor promoting and immunosuppressive effects of the CD70-CD27 axis has unfolded a novel target in the field of oncology, CD70.In this review, we thoroughly discuss current insights into expression patterns and the role of the CD70-CD27 axis in hematological and solid malignancies, its effect on the tumor microenvironment and (pre)clinical therapeutic strategies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Riether, Carsten

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1756-9966

Publisher:

BioMed Central

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

22 Feb 2022 15:57

Last Modified:

27 Feb 2022 01:56

Publisher DOI:

10.1186/s13046-021-02215-y

PubMed ID:

34991665

Uncontrolled Keywords:

CD27 CD70 Combination therapies Hematological malignancies Hematopoiesis Oncology Solid tumors

BORIS DOI:

10.48350/165339

URI:

https://boris.unibe.ch/id/eprint/165339

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