Förger, Frauke; Ostensen, Monika (2010). Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis? Arthritis research & therapy, 12(1), p. 108. London: BioMed Central 10.1186/ar2919
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During pregnancy, most patients with rheumatoid arthritis (RA) experience spontaneous improvement of their disease activity. Among the soluble candidates that have been investigated in search for the most relevant disease-remitting factor are the galactosylation levels of immunoglobulin G (IgG). In RA, a higher percentage of IgG lacking the terminal galactose residues, thought to play a pro-inflammatory role, is found. During pregnancy, however, IgG galactosylation levels increase and correlate with improved disease activity. The question remains whether the increase in IgG galactosylation during pregnancy is a mere epiphenomenon or a true remission-inducing factor.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology |
UniBE Contributor: |
Förger, Frauke, Oestensen, Monika Elisabeth |
ISSN: |
1478-6354 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:10 |
Last Modified: |
05 Dec 2022 14:01 |
Publisher DOI: |
10.1186/ar2919 |
PubMed ID: |
20236448 |
Web of Science ID: |
000278012700008 |
BORIS DOI: |
10.7892/boris.1654 |
URI: |
https://boris.unibe.ch/id/eprint/1654 (FactScience: 203491) |
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