Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis?

Förger, Frauke; Ostensen, Monika (2010). Is IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis? Arthritis research & therapy, 12(1), p. 108. London: BioMed Central 10.1186/ar2919

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During pregnancy, most patients with rheumatoid arthritis (RA) experience spontaneous improvement of their disease activity. Among the soluble candidates that have been investigated in search for the most relevant disease-remitting factor are the galactosylation levels of immunoglobulin G (IgG). In RA, a higher percentage of IgG lacking the terminal galactose residues, thought to play a pro-inflammatory role, is found. During pregnancy, however, IgG galactosylation levels increase and correlate with improved disease activity. The question remains whether the increase in IgG galactosylation during pregnancy is a mere epiphenomenon or a true remission-inducing factor.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Förger, Frauke and Oestensen, Monika Elisabeth

ISSN:

1478-6354

Publisher:

BioMed Central

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

05 Dec 2014 09:37

Publisher DOI:

10.1186/ar2919

PubMed ID:

20236448

Web of Science ID:

000278012700008

BORIS DOI:

10.7892/boris.1654

URI:

https://boris.unibe.ch/id/eprint/1654 (FactScience: 203491)

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