Reproducibility of 4D cardiac computed tomography feature tracking myocardial strain and comparison against speckle-tracking echocardiography in patients with severe aortic stenosis.

Bernhard, Benedikt; Grogg, Hanna; Zurkirchen, Jan; Demirel, Caglayan; Hagemeyer, Daniel; Okuno, Taishi; Brugger, Nicolas; De Marchi, Stefano; Huber, Adrian T.; Boscolo Berto, Martina; Spano, Giancarlo; Stortecky, Stefan; Windecker, Stephan; Pilgrim, Thomas; Gräni, Christoph (2022). Reproducibility of 4D cardiac computed tomography feature tracking myocardial strain and comparison against speckle-tracking echocardiography in patients with severe aortic stenosis. Journal of cardiovascular computed tomography, 16(4), pp. 309-318. Elsevier 10.1016/j.jcct.2022.01.003

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BACKGROUND

Myocardial strain is an established parameter for the assessment of cardiac function and routinely derived from speckle tracking echocardiography (STE). Novel post-processing tools allow deformation imaging also by 4D cardiac computed tomography angiography (CCT). This retrospective study aims to analyze the reproducibility of CCT strain and compare it to that of STE.

METHODS

Left (LV) and right ventricular (RV), and left atrial (LA) ejection fraction (EF), dimensions, global longitudinal (GLS), circumferential (GCS) and radial strain (GRS) were determined by STE and CCT feature tracking in consecutive patients with severe aortic stenosis evaluated for transcatheter aortic valve implantation.

RESULTS

106 patients (mean age 79.9 ​± ​7.8, 44.3% females) underwent CCT at a median of 3 days (IQR 0-28 days) after STE. In CCT, strain measures showed good to excellent reproducibility (intra- and inter-reader intraclass correlation coefficient ≥0.75) consistently in the LV, RV and LA. In STE, only LV GLS and LA GLS yielded good reproducibility, whereas LV GCS and LV GRS showed moderate, and RV GLS and free wall longitudinal strain (FWLS) poor reproducibility. Agreement between CCT and STE was strong for LV GLS only, while other strain features displayed moderate (LV GCS, LA GLS) or weak (LV GRS, RV GLS and FWLS) inter-modality correlation.

CONCLUSION

LV, RV and LA CCT strain assessments were highly reproducible. While a strong agreement to STE was found for LV GLS, inter-modality correlation was moderate or weak for LV GCS, LV GRS, and RV and LA longitudinal strain, possibly related to poor reproducibility of STE measurements.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Bernhard, Benedikt, Demirel, Caglayan, Hagemeyer, Daniel Philipp Alfons, Okuno, Taishi, Brugger, Nicolas Jacques, De Marchi, Stefano, Huber, Adrian Thomas, Boscolo Berto, Martina, Spano, Giancarlo, Stortecky, Stefan, Windecker, Stephan, Pilgrim, Thomas, Gräni, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1876-861X

Publisher:

Elsevier

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

02 Mar 2022 15:48

Last Modified:

05 Dec 2022 16:08

Publisher DOI:

10.1016/j.jcct.2022.01.003

PubMed ID:

35148996

Uncontrolled Keywords:

4D cardiac computed tomography Deformation imaging Feature tracking Global longitudinal strain Myocardial strain Speckle-tracking echocardiography

BORIS DOI:

10.48350/165440

URI:

https://boris.unibe.ch/id/eprint/165440

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