Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression.

Bracht, Tobias; Mertse, Nicolas; Walther, Sebastian; Lüdi, Karin; Breit, Sigrid; Federspiel, Andrea; Wiest, Roland; Denier, Niklaus (2022). Link between structural connectivity of the medial forebrain bundle, functional connectivity of the ventral tegmental area, and anhedonia in unipolar depression. NeuroImage: Clinical, 34, p. 102961. Elsevier 10.1016/j.nicl.2022.102961

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The ventral tegmental area (VTA), nucleus accumbens (NAcc), and prefrontal cortex (PFC) are essential for experiencing pleasure and initiating motivated behaviour. The VTA, NAcc, and PFC are connected through the medial forebrain bundle (MFB). In humans, two branches have been described: an infero-medial branch (imMFB) and a supero-lateral branch (slMFB). This study aimed to explore the associations between structural connectivity of the MFB, functional connectivity (FC) of the VTA, anhedonia, and depression severity in patients with depression. Fifty-six patients with unipolar depression and 22 healthy controls matched for age, sex, and handedness were recruited at the University Hospital of Psychiatry and Psychotherapy in Bern, Switzerland. Diffusion-weighted imaging and resting-state functional magnetic resonance imaging scans were acquired. Using manual tractography, the imMFB and slMFB were reconstructed bilaterally for each participant. Seed-based resting-state FC was computed from the VTA to the PFC. Hedonic tone was assessed using the Fawcett-Clark Pleasure Scale. We identified reduced tract volume and reduced number of tracts in the left slMFB. There was an increase in FC between the VTA and right medial PFC in patients with depression. Depression severity was associated with reduced tract volume and fewer tracts in the left slMFB. Reduced hedonic tone was associated with reduced tract volume. Conversely, reduced hedonic tone was associated with increased FC between the VTA and the PFC. In conclusion, our results suggest reduced structural connectivity of the slMFB in patients with depression. Increases in FC between the VTA and PFC may be associated with anhedonia or compensatory hyperactivity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

UniBE Contributor:

Bracht, Tobias, Nagysomkuti Mertse, Nicolas Maximilien, Walther, Sebastian, Breit, Sigrid, Federspiel, Andrea, Wiest, Roland Gerhard Rudi, Denier, Niklaus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2213-1582

Publisher:

Elsevier

Language:

English

Submitter:

Sebastian Walther

Date Deposited:

22 Feb 2022 18:46

Last Modified:

02 Mar 2023 23:35

Publisher DOI:

10.1016/j.nicl.2022.102961

PubMed ID:

35152053

Uncontrolled Keywords:

Anhedonia Depression Diffusion tensor imaging Functional MRI Medial forebrain bundle Reward system

BORIS DOI:

10.48350/165475

URI:

https://boris.unibe.ch/id/eprint/165475

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