The plasmin-antiplasmin system: structural and functional aspects

Schaller, Johann; Gerber, Simon S (2011). The plasmin-antiplasmin system: structural and functional aspects. Cellular and molecular life sciences, 68(5), pp. 785-801. Basel: SP Birkhäuser Verlag Basel 10.1007/s00018-010-0566-5

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The plasmin-antiplasmin system plays a key role in blood coagulation and fibrinolysis. Plasmin and (2)-antiplasmin are primarily responsible for a controlled and regulated dissolution of the fibrin polymers into soluble fragments. However, besides plasmin(ogen) and (2)-antiplasmin the system contains a series of specific activators and inhibitors. The main physiological activators of plasminogen are tissue-type plasminogen activator, which is mainly involved in the dissolution of the fibrin polymers by plasmin, and urokinase-type plasminogen activator, which is primarily responsible for the generation of plasmin activity in the intercellular space. Both activators are multidomain serine proteases. Besides the main physiological inhibitor (2)-antiplasmin, the plasmin-antiplasmin system is also regulated by the general protease inhibitor (2)-macroglobulin, a member of the protease inhibitor I39 family. The activity of the plasminogen activators is primarily regulated by the plasminogen activator inhibitors 1 and 2, members of the serine protease inhibitor superfamily.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Schaller, Johann and Gerber, Simon

ISSN:

1420-682X

Publisher:

SP Birkhäuser Verlag Basel

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

26 Jun 2018 15:40

Publisher DOI:

10.1007/s00018-010-0566-5

PubMed ID:

21136135

Web of Science ID:

000287243400004

BORIS DOI:

10.7892/boris.1656

URI:

https://boris.unibe.ch/id/eprint/1656 (FactScience: 203508)

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