Do clinimetric properties of LCI change after correction of signal processing?

Frauchiger, Bettina Sarah; Oestreich, Marc-Alexander; Wyler, Florian; Monney, Nathalie; Willers, Corin; Yammine, Sophie; Latzin, Philipp (2022). Do clinimetric properties of LCI change after correction of signal processing? Pediatric pulmonology, 57(5), pp. 1180-1187. Wiley-Blackwell 10.1002/ppul.25865

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BACKGROUND

The recently described sensor-crosstalk error in the multiple-breath washout (MBW) device Exhalyzer D (Eco Medics AG, Duernten, Switzerland) could highly influence clinimetric properties and the current interpretation of MBW results. This study reanalyzes MBW data from clinical routine in the corrected software version Spiroware® 3.3.1 and evaluates the effect on outcomes.

METHODS

We included nitrogen-MBW data from healthy children and children with cystic fibrosis (CF) from previously published trials and ongoing cohort studies. We specifically compared lung clearance index (LCI) analyzed in Spiroware 3.2.1 and 3.3.1 with regards to i) feasibility, ii) repeatability and iii) validity as outcome parameters in children with CF.

RESULTS

(i) All previously collected measurements could be reanalyzed and resulted in unchanged feasibility in Spiroware 3.3.1. (ii) Short- and midterm repeatability of LCI was similar in both software versions. (iii) Clinical validity of LCI remained similar in Spiroware 3.3.1, however, resulted in lower values. Discrimination between health and disease was comparable between both software versions. The increase in LCI over time was less pronounced with 0.16 LCI units/year (95% CI 0.08; 0.24) vs. 0.30 LCI units/year (95% CI 0.21; 0.38) in 3.2.1. Response to intervention in children receiving CFTR-modulator therapy resulted in a comparable improvement in LCI in both Spiroware versions.

CONCLUSION

Our study confirms that clinimetric properties of LCI remain unaffected after correction for the cross-sensitivity error in Spiroware software. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Frauchiger, Bettina Sarah; Oestreich, Marc-Alexander Heinz; Wyler, Florian; Willers, Christoph Corin; Yammine, Sophie and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

8755-6863

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

21 Feb 2022 07:39

Last Modified:

05 Dec 2022 16:09

Publisher DOI:

10.1002/ppul.25865

PubMed ID:

35182057

Uncontrolled Keywords:

Cystic fibrosis Multiple-breath washout pulmonary function testing

BORIS DOI:

10.48350/165757

URI:

https://boris.unibe.ch/id/eprint/165757

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