Low placental weight and altered metabolic scaling after severe acute respiratory syndrome coronavirus type 2 infection during pregnancy: a prospective multicentric study.

Radan, Anda-Petronela; Baud, David; Favre, Guillaume; Papadia, Andrea; Surbek, Daniel; Baumann, Marc; Raio, Luigi (2022). Low placental weight and altered metabolic scaling after severe acute respiratory syndrome coronavirus type 2 infection during pregnancy: a prospective multicentric study. Clinical microbiology and infection, 28(5), pp. 718-722. Elsevier 10.1016/j.cmi.2022.02.003

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OBJECTIVES

A higher risk for adverse pregnancy outcome is associated with SARS-CoV-2 infection, which could be partially explained by an altered placental function. Since histopathology is often unspecific, we aimed to assess placental weight, birthweight/placental-weight (b/p) ratio and the metabolic scaling exponent ß, an indicator of a normal fetal-placental growth, in order to analyze the placental function.

METHODS

We included 153 singleton pregnancies with SARS-CoV-2 positive PCR in our study, who delivered at three referring hospitals in Switzerland. Placental weight and b/p ratio were compared to published reference charts. Logistic regression analysis investigated the role of time of infection and other confounding factors on placental weight. The scaling exponent β was compared to the reference value of ¾.

RESULTS

Placental weight was inferior or equal to the 10th centile in 42.5%(65/153) and to the 3rd centile in 19%(29/153) of the cases. The risk of low placental weight was not influenced by the trimester of infection. B/p ratio was >50th centile in 80.4%(123/153) of the cases. Incidence of fetal growth restriction, preeclampsia and gestational diabetes was 11.8%(18/153), 3.3%(5/153) and 19.6%(30/153). Linear regression modelling revealed a pathologic metabolic scaling exponent β of 0.871±0.064 (R2=0.56).

CONCLUSION

SARS-CoV-2 during pregnancy was associated with a higher incidence of low placental weight, an increased b/p ratio and an abnormal scaling exponent β in our cohort. This could be particularly relevant for the yet controversial issue of increased stillbirth rate in SARS-CoV-2 infection during pregnancy. In this regard, intensified fetal surveillance should be mandatory in these pregnancies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Radan, Anda-Petronela; Surbek, Daniel; Baumann, Marc and Raio, Luigi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1469-0691

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

21 Feb 2022 16:23

Last Modified:

02 May 2022 00:13

Publisher DOI:

10.1016/j.cmi.2022.02.003

PubMed ID:

35150886

Uncontrolled Keywords:

Birthweight/placental weight ratio COVID-19 Metabolic scaling exponent β SARS-CoV-2 gestational diabetes placental weight

BORIS DOI:

10.48350/165822

URI:

https://boris.unibe.ch/id/eprint/165822

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