Buchmann, Andreas; Ritter, Christopher; Müller, Sabrina Theresia; Haynes, Melanie; Ghisleni, Carmen; Tuura, Ruth; Hasler, Gregor (2022). Associations between Heart Rate Variability, Peripheral Inflammatory Markers and Major Depressive Disorder. Journal of affective disorders, 304, pp. 93-101. Elsevier 10.1016/j.jad.2022.02.017
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BACKGROUND
Measures for the irregularity of the heartbeat, for example respiratory sinus arrhythmia, have been implicated as a measure for restorative functions of the vegetative nervous system.
METHODS
In the current observational study, we investigated 265 subjects, 70 of whom had a lifetime history of major depression, with a plethysmographic heartbeat monitor, blood sampling, as well as a range of psychiatric questionnaires.
RESULTS
Subjects with a history of MDE had significantly reduced respiratory sinus arrhythmia (RSA) as compared to never-depressed controls; in the whole sample, higher RSA went with lower anxiety/fear variables, especially in subscores related to cardiac symptoms as well as being afraid of dying. A reduced RSA was also associated with an increased concentration of cytokines (TNFa, IL1a, IL6, IFNg) and thyroid-stimulating hormone in the serum, pointing to a possible triangular relationship between immune system, vegetative nervous system, and emotional dysregulation.
LIMITATIONS
We used a plethysmographic device for the measurement of heartbeat instead of an electrocardiogram, and had a single time point only.
CONCLUSIONS
This data corroborate the idea that a disequilibrium of the vegetative nervous, especially if accompanied by a dysregulation system in immune function, can increase the risk for depression. Conversely, vagal stimulation and anti-inflammatory treatments may support the treatment with antidepressants.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center |
UniBE Contributor: |
Haynes, Melanie |
ISSN: |
1573-2517 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
24 Feb 2022 10:03 |
Last Modified: |
05 Dec 2022 16:10 |
Publisher DOI: |
10.1016/j.jad.2022.02.017 |
PubMed ID: |
35196535 |
Uncontrolled Keywords: |
anxiety depression heartbeat variability inflammation respiratory sinus arrhythmia vagus |
BORIS DOI: |
10.48350/165975 |
URI: |
https://boris.unibe.ch/id/eprint/165975 |
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