Associations between Heart Rate Variability, Peripheral Inflammatory Markers and Major Depressive Disorder.

Buchmann, Andreas; Ritter, Christopher; Müller, Sabrina Theresia; Haynes, Melanie; Ghisleni, Carmen; Tuura, Ruth; Hasler, Gregor (2022). Associations between Heart Rate Variability, Peripheral Inflammatory Markers and Major Depressive Disorder. Journal of affective disorders, 304, pp. 93-101. Elsevier 10.1016/j.jad.2022.02.017

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BACKGROUND

Measures for the irregularity of the heartbeat, for example respiratory sinus arrhythmia, have been implicated as a measure for restorative functions of the vegetative nervous system.

METHODS

In the current observational study, we investigated 265 subjects, 70 of whom had a lifetime history of major depression, with a plethysmographic heartbeat monitor, blood sampling, as well as a range of psychiatric questionnaires.

RESULTS

Subjects with a history of MDE had significantly reduced respiratory sinus arrhythmia (RSA) as compared to never-depressed controls; in the whole sample, higher RSA went with lower anxiety/fear variables, especially in subscores related to cardiac symptoms as well as being afraid of dying. A reduced RSA was also associated with an increased concentration of cytokines (TNFa, IL1a, IL6, IFNg) and thyroid-stimulating hormone in the serum, pointing to a possible triangular relationship between immune system, vegetative nervous system, and emotional dysregulation.

LIMITATIONS

We used a plethysmographic device for the measurement of heartbeat instead of an electrocardiogram, and had a single time point only.

CONCLUSIONS

This data corroborate the idea that a disequilibrium of the vegetative nervous, especially if accompanied by a dysregulation system in immune function, can increase the risk for depression. Conversely, vagal stimulation and anti-inflammatory treatments may support the treatment with antidepressants.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Haynes, Melanie

ISSN:

1573-2517

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

24 Feb 2022 10:03

Last Modified:

05 Dec 2022 16:10

Publisher DOI:

10.1016/j.jad.2022.02.017

PubMed ID:

35196535

Uncontrolled Keywords:

anxiety depression heartbeat variability inflammation respiratory sinus arrhythmia vagus

BORIS DOI:

10.48350/165975

URI:

https://boris.unibe.ch/id/eprint/165975

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