Male breast cancer after childhood cancer: Systematic review and analyses in the PanCareSurFup cohort.

Wang, Yuehan; Reulen, Raoul C; Kremer, Leontien C M; de Vathaire, Florent; Haupt, Riccardo; Zadravec Zaletel, Lorna; Bagnasco, Francesca; Demoor-Goldschmidt, Charlotte; van Dorp, Willem J; Haddy, Nadia; Hjorth, Lars; Jakab, Zsuzsanna; Kuehni, Claudia E; Lähteenmäki, Päivi M; van der Pal, Helena J H; Sacerdote, Carlotta; Skinner, Roderick; Terenziani, Monica; Wesenberg, Finn; Winther, Jeanette F; ... (2022). Male breast cancer after childhood cancer: Systematic review and analyses in the PanCareSurFup cohort. European journal of cancer, 165, pp. 27-47. Elsevier 10.1016/j.ejca.2022.01.001

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BACKGROUND

Breast cancer is a well-recognised late adverse effect in female childhood cancer survivors (CCSs), especially after chest radiotherapy; information on subsequent male breast cancer (SMBC) is limited. We summarised the existing evidence on SMBC after childhood cancer in a systematic review and investigated the risk of SMBC among males in a Pan-European cohort.

METHODS

We searched Medline/PubMed for cohort studies and case reports/series that assessed SMBC after childhood cancer (≤21 years). Furthermore, we analysed data on SMBC in the PanCareSurFup cohort, reporting standardised incidence ratios (SIRs), absolute excess risks (AERs), and 5- and 10-year survival rates.

RESULTS

The systematic review included 38 of 7080 potentially eligible articles. Cohort-specific SMBC frequencies were 0-0.40% (31 studies). SMBC occurred after a follow-up ranging from 24.0 to 42.0 years. Nine case reports/series described 11 SMBC cases, occurring 11.0-42.5 years after primary childhood cancer. In the PanCareSurFup cohort (16 SMBC/37,738 males; 0.04%), we observed a 22.3-fold increased risk of SMBC relative to the general male population (95% CI 12.7-36.2; absolute excess risk/100,000 person-years: 2.3, 95% CI 1.3-3.7). The five- and ten-year survival rates after SMBC diagnosis were 60.3% (95% CI 35.6%-85.0%) and 43.0% (95% CI 16.1%-69.9%), respectively. Clear evidence of risk factors did not emerge from these comprehensive efforts.

CONCLUSIONS

Compared to the general population, male CCSs have an elevated risk of developing subsequent breast cancer, although the absolute risk is low. Health care providers should be aware of this rare yet serious late effect; male CCSs with symptoms potentially related to SMBC warrant careful examination.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Haematology/Oncology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Kühni, Claudia

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0959-8049

Publisher:

Elsevier

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

25 Feb 2022 11:10

Last Modified:

23 Feb 2023 00:25

Publisher DOI:

10.1016/j.ejca.2022.01.001

PubMed ID:

35202973

Uncontrolled Keywords:

Childhood cancer survivors Cohort study Data analyses Late effects Male breast cancer Second cancer Systematic review

BORIS DOI:

10.48350/166023

URI:

https://boris.unibe.ch/id/eprint/166023

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