Fung, Christian; Heiland, Dieter Henrik; Reitmeir, Raluca; Niesen, Wolf-Dirk; Raabe, Andreas; Eyding, Jens; Schnell, Oliver; Rölz, Roland; Z'Graggen, Werner J; Beck, Jürgen (2022). Ultrasound Perfusion Imaging for the Detection of Cerebral Hypoperfusion After Aneurysmal Subarachnoid Hemorrhage. Neurocritical care, 37(1), pp. 149-159. Springer 10.1007/s12028-022-01460-z
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BACKGROUND
Delayed cerebral ischemia increases mortality and morbidity after aneurysmal subarachnoid hemorrhage (aSAH). Various techniques are applied to detect cerebral vasospasm and hypoperfusion. Contrast-enhanced ultrasound perfusion imaging (UPI) is able to detect cerebral hypoperfusion in acute ischemic stroke. This prospective study aimed to evaluate the use of UPI to enable detection of cerebral hypoperfusion after aSAH.
METHODS
We prospectively enrolled patients with aSAH and performed UPI examinations every second day after aneurysm closure. Perfusion of the basal ganglia was outlined to normalize the perfusion records of the anterior and posterior middle cerebral artery territory. We applied various models to characterize longitudinal perfusion alterations in patients with delayed ischemic neurologic deficit (DIND) across the cohort and predict DIND by using a multilayer classification model.
RESULTS
Between August 2013 and December 2015, we included 30 patients into this prospective study. The left-right difference of time to peak (TTP) values showed a significant increase at day 10-12. Patients with DIND demonstrated a significant, 4.86 times increase of the left-right TTP ratio compared with a mean fold change in patients without DIND of 0.9 times (p = 0.032).
CONCLUSIONS
UPI is feasible to enable detection of cerebral tissue hypoperfusion after aSAH, and the left-right difference of TTP values is the most indicative result of this finding.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Reitmeir, Raluca, Raabe, Andreas, Z'Graggen, Werner Josef |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1541-6933 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
01 Mar 2022 08:58 |
Last Modified: |
05 Dec 2022 16:10 |
Publisher DOI: |
10.1007/s12028-022-01460-z |
PubMed ID: |
35211837 |
Uncontrolled Keywords: |
Perfusion Subarachnoid hemorrhage Ultrasonography Vasospasm (intracranial) |
BORIS DOI: |
10.48350/166085 |
URI: |
https://boris.unibe.ch/id/eprint/166085 |
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