Impact of Partial Volume Correction on [18F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome.

Schuster, Sebastian; Beyer, Leonie; Palleis, Carla; Harris, Stefanie; Schmitt, Julia; Weidinger, Endy; Prix, Catharina; Bötzel, Kai; Danek, Adrian; Rauchmann, Boris-Stephan; Stöcklein, Sophia; Lindner, Simon; Unterrainer, Marcus; Albert, Nathalie L; Mittlmeier, Lena M; Wetzel, Christian; Rupprecht, Rainer; Rominger, Axel; Bartenstein, Peter; Perneczky, Robert; ... (2022). Impact of Partial Volume Correction on [18F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome. Brain Sciences, 12(2) MDPI 10.3390/brainsci12020204

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Corticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial volume effect correction (PVEC) in patients with CBS compared to a control cohort imaged with the 18-kDa translocator protein (TSPO) positron emission tomography (PET) tracer [18F]GE-180. Eighteen patients with CBS and 12 age- and sex-matched healthy controls underwent [18F]GE-180 PET. The cortical and subcortical regions were delineated by deep nuclei parcellation (DNP) of a 3D-T1 MRI. Region-specific subcortical volumes and standardized uptake values and ratios (SUV and SUVr) were extracted before and after region-based voxel-wise PVEC. Regional volumes were compared between patients with CBS and controls. The % group differences and effect sizes (CBS vs. controls) of uncorrected and PVE-corrected SUVr data were compared. Single-region positivity in patients with CBS was assessed by a >2 SD threshold vs. controls and compared between uncorrected and PVE-corrected data. Smaller regional volumes were detected in patients with CBS compared to controls in the right ventral striatum (p = 0.041), the left putamen (p = 0.005), the right putamen (p = 0.038) and the left pallidum (p = 0.015). After applying PVEC, the % group differences were distinctly higher, but the effect sizes of TSPO uptake were only slightly stronger due to the higher variance after PVEC. The single-region positivity of TSPO PET increased in patients with CBS after PVEC (100 vs. 83 regions). PVEC in the cortical and subcortical regions is valuable for TSPO imaging of patients with CBS, leading to the improved detection of elevated [18F]GE-180 uptake, although the effect sizes in the comparison against the controls did not improve strongly.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Rominger, Axel Oliver

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2076-3425

Publisher:

MDPI

Language:

English

Submitter:

Pubmed Import

Date Deposited:

28 Feb 2022 16:16

Last Modified:

28 Feb 2022 16:23

Publisher DOI:

10.3390/brainsci12020204

PubMed ID:

35203967

Uncontrolled Keywords:

TSPO PET [18F]GE-180 corticobasal syndrome partial volume effect positron emission tomography subcortical atrophy

BORIS DOI:

10.48350/166111

URI:

https://boris.unibe.ch/id/eprint/166111

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