Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 - Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes.

Schlichtner, Stephanie; Yasinska, Inna M; Ruggiero, Sabrina; Berger, Steffen M; Aliu, Nijas; Prunk, Mateja; Kos, Janko; Meyer, N Helge; Gibbs, Bernhard F; Fasler-Kan, Elizaveta; Sumbayev, Vadim V (2022). Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 - Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes. Frontiers in medicine, 9, p. 790995. Frontiers 10.3389/fmed.2022.790995

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Immune checkpoint proteins play crucial roles in human embryonic development but are also used by cancer cells to escape immune surveillance. These proteins and biochemical pathways associated with them form a complex machinery capable of blocking the ability of cytotoxic immune lymphoid cells to attack cancer cells and, ultimately, to fully suppress anti-tumor immunity. One of the more recently discovered immune checkpoint proteins is V-domain Ig-containing suppressor of T cell activation (VISTA), which plays a crucial role in anti-cancer immune evasion pathways. The biochemical mechanisms underlying regulation of VISTA expression remain unknown. Here, we report for the first time that VISTA expression is controlled by the transforming growth factor beta type 1 (TGF-β)-Smad3 signaling pathway. However, in T lymphocytes, we found that VISTA expression was differentially regulated by TGF-β depending on their immune profile. Taken together, our results demonstrate the differential biochemical control of VISTA expression in human T cells and various types of rapidly proliferating cells, including cancer cells, fetal cells and keratinocytes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinics of Human Genetics

UniBE Contributor:

Ruggiero, Sabrina; Berger, Steffen Michael; Aliu, Nijas and Fasler-Kan, Elizaveta

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2296-858X

Publisher:

Frontiers

Language:

English

Submitter:

Pubmed Import

Date Deposited:

01 Mar 2022 09:55

Last Modified:

06 Mar 2022 01:54

Publisher DOI:

10.3389/fmed.2022.790995

PubMed ID:

35223897

Uncontrolled Keywords:

T lymphocytes VISTA anti-cancer immunity galectin-9 immune checkpoint

BORIS DOI:

10.48350/166212

URI:

https://boris.unibe.ch/id/eprint/166212

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