Negative mood regulation as a mechanism of change in cognitive therapy for depression

Areas, Malenka; Penedo, Juan Martín Gómez; Alalú, Nicolás; Babl, Anna Margarete; Roussos, Andrés; grosse Holtforth, Martin (2021). Negative mood regulation as a mechanism of change in cognitive therapy for depression. Psychotherapy, 58(4), pp. 485-492. 10.1037/pst0000373

2021-Areasetal.-Psycotherapy.docx.pdf - Accepted Version
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The present study investigates the effects of negative mood regulation expectancies (NMRE) on symptom severity of depression in two cognitive therapies for depression. The sample included the first 146 consecutively recruited patients from a randomized controlled trial. Patients received 22 sessions of either cognitive behavioral therapy (CBT) or exposure based cognitive therapy (EBCT). They completed the Beck Depression Inventory and Negative Mood Regulation Scale at baseline and treatment termination, as well as after sessions seven and 14. Multilevel modeling was applied. We found a significant between-patient effect of NMRE on symptom severity of depression, when NMRE within-patient effects were set to random. There was no significant interactive effect of the between-patient NMRE with type of treatment. However, a significant moderation effect of the within-patient NMRE effect by treatment condition on depression severity was detected, with patients receiving CBT benefiting more from improvements in NMRE. Together, these results empirically support NMRE as a relevant mechanism of change in cognitive therapy for depression.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy

UniBE Contributor:

Babl, Anna Margarete, Grosse Holtforth, Martin


600 Technology > 610 Medicine & health






Melanie Best

Date Deposited:

09 Mar 2022 11:22

Last Modified:

05 Dec 2022 16:11

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Negative mood regulation expectancies; change mechanisms; depression; exposure-based cognitive therapy; cognitive-behavioral therapy




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