Association Between Ultra-Processed Food Intake and All-Cause Mortality: A Systematic Review and Meta-Analysis.

Taneri, Petek Eylul; Wehrli, Faina; Roa Diaz, Zayne M; Itodo, Oche Adam; Salvador, Dante; Raeisi-Dehkordi, Hamidreza; Bally, Lia; Minder, Beatrice; Kiefte-de Jong, Jessica C; Laine Carmeli, Jessica; Bano, Arjola; Glisic, Marija; Muka, Taulant (2022). Association Between Ultra-Processed Food Intake and All-Cause Mortality: A Systematic Review and Meta-Analysis. American journal of epidemiology, 191(7), pp. 1323-1335. Oxford University Press 10.1093/aje/kwac039

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Ultra-processed food (UPF) consumption have increased in the world during the last decades since they are hyper-palatable, cheap and ready-to-consume products. However, uncertainty exists on their impact on health. We conducted a systematic review and meta-analysis evaluating the association of UPF consumption with the all-cause mortality risk. Five bibliographic databases were searched for relevant studies. Random effects models were used to calculate pooled relative risks (RR) and 95% confidence intervals (CI). Of 6,951 unique citations, 40 unique prospective cohort studies comprising 5,750,133 individuals were included. Publication date of the included studies ranged from 1984 to2021. Compared to low consumption, highest consumption of UPF (RR=1.29, 95% CI 1.17-1.42), sugar-sweetened beverages (SSB) (RR=1.11, 95% CI, 1.04-1.18), artificially sweetened beverages (ASB) (RR=1.14, 95% CI, 1.05-1.22) and processed meat/red meat (RR=1.15, 95% CI, 1.10-1.21) were significantly associated with increased risk of mortality. On the contrary, breakfast cereals were associated with a lower mortality risk (RR=0.85, 95% CI, 0.79-0.92). Conclusion: This meta-analysis suggests that high consumption of UPF, SSB, ASB, processed meat and processed red meat might increase all-cause mortality, while breakfast cereals might decrease it. Future studies are needed to address lack of standardized methods in UPF categorization.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
13 Central Units > Administrative Director's Office > University Library of Bern
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Taneri, Petek Eylul, Wehrli, Faina, Roa Diaz, Zayne Milena, Itodo, Oche Adam, Salvador, Dante Jr., Bally, Lia Claudia, Minder, Beatrice, Laine Carmeli, Jessica Evelyn, Bano, Arjola, Glisic, Marija, Muka, Taulant


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
000 Computer science, knowledge & systems > 020 Library & information sciences




Oxford University Press




Pubmed Import

Date Deposited:

03 Mar 2022 11:16

Last Modified:

03 Mar 2023 00:25

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Uncontrolled Keywords:

All-cause mortality Artifically-sweetened beverages Sugar-sweetened beverages Ultra-processed foods breakfast cereals processed meat




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