Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1

Orrling, KM; Jansen, C; Vu, XL; Balmer, V; Bregy, P; Shanmugham, A; England, P; Bailey, D; Cos, P; Maes, L; Adams, E; van den Bogaart, E; Chatelain, E; Ioset, JR; van de Stolpe, A; Zorg, S; Veerman, J; Seebeck, T; Sterk, GJ; de Esch, IJ; ... (2012). Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1. Journal of medicinal chemistry, 55(20), pp. 8645-8756. Easton, Pa.: American Chemical Society 10.1021/jm301059b

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Item Type:	Journal Article (Original Article)
Division/Institute:	08 Faculty of Science > Department of Biology > Institute of Cell Biology
UniBE Contributor:	Seebeck, Thomas
ISSN:	0022-2623
Publisher:	American Chemical Society
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:41
Last Modified:	05 Dec 2022 14:12
Publisher DOI:	10.1021/jm301059b
Web of Science ID:	000310120700015
URI:	https://boris.unibe.ch/id/eprint/16654 (FactScience: 224338)