Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes

Lolo, F.; Casas-Tinto, S.; Moreno, E. (2012). Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes. Cell reports, 2(3), pp. 526-539. Cambridge, Mass.: Cell Press 10.1016/j.celrep.2012.08.012

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Cell competition is a mechanism that eliminates slow dividing cells from a growing population. It is believed that the genes wasp, psr, and draper are active in the cells that win the competition ("winner cells") and that they are essential in the winner cells for the induction of apoptosis and for the elimination of the "loser cells." Here, we show that lack of those genes in winner cells appears to be dispensable for cell-competition-induced apoptosis and during dmyc-induced supercompetition. Moreover, winner clones do not need those genes in order to preserve their growth advantage. Finally, we find that most of the clearance of the apoptotic debris is not performed by winners but by recruited hemocytes, which are required for the removal of the apoptotic corpses at the very end. Therefore, engulfment is a consequence-not a cause-of loser cells' death.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Moreno, Eduardo

ISSN:

2211-1247

Publisher:

Cell Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:41

Last Modified:

22 Jun 2016 17:51

Publisher DOI:

10.1016/j.celrep.2012.08.012

PubMed ID:

22981235

Web of Science ID:

000309716200013

BORIS DOI:

10.7892/boris.16657

URI:

https://boris.unibe.ch/id/eprint/16657 (FactScience: 224342)

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