Impact of progesterone on the gastrointestinal tract: a comprehensive literature review.

Coquoz, A; Regli, D; Stute, P (2022). Impact of progesterone on the gastrointestinal tract: a comprehensive literature review. Climacteric, 25(4), pp. 337-361. Taylor & Francis 10.1080/13697137.2022.2033203

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Women are more prone to gastrointestinal symptoms than men. A comprehensive literature search was performed to assess the impact of sex steroid hormone, especially progesterone, on the (healthy and diseased) gastrointestinal tract. Overall, 37 articles were identified. Based on these we conclude that progesterone has a dose-dependent and sex-dependent effect on gastric emptying (especially in mammals), slows down gastrointestinal motility, reduces the gallbladder's response to contractile stimulants, may support gastroesophageal reflux by reducing the esophageal sphincter pressure, may protect from Helicobacter pylori infection gastrointestinal sequelae (especially in mammals) and does not affect inflammatory bowel disease-specific symptoms. However, for several gastrointestinal symptoms and diseases no studies have yet been performed addressing the impact of sex hormone steroids.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Coquoz, Audrey, Stute, Petra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1473-0804

Publisher:

Taylor & Francis

Language:

English

Submitter:

Pubmed Import

Date Deposited:

08 Mar 2022 09:26

Last Modified:

05 Dec 2022 16:13

Publisher DOI:

10.1080/13697137.2022.2033203

PubMed ID:

35253565

Uncontrolled Keywords:

Micronized progesterone estrogens gallbladder motility gastroesophageal reflux gastrointestinal motility gastrointestinal ulcers inflammatory bowel disease menopause

URI:

https://boris.unibe.ch/id/eprint/166742

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