Mancuso, M; Houlden, H; Molnar, M J; Filla, A; Breza, M; Graessner, H; Bassetti, CLA; Boesch, S (2022). How to approach a neurogenetics diagnosis in different European countries - The EAN Neurogenetics Panel survey. European journal of neurology, 29(7), pp. 1885-1891. Wiley 10.1111/ene.15320
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Euro_J_of_Neurology_-_2022_-_Mancuso_-_How_to_approach_a_neurogenetics_diagnosis_in_different_European_countries_The_EAN.pdf - Accepted Version Available under License Publisher holds Copyright. Download (8MB) | Preview |
BACKGROUND AND PURPOSE
7,000 rare diseases have been identified, most of them are of genetic origin. The diagnosis of a neurogenetic disease is difficult, and management and training programs are not well defined through Europe. To capture and assess care needs, the Neurogenetics Panel of the European Academy of Neurology (EAN) has performed an explorative survey.
METHODS
The survey covering multiple topics of neurogenetics was sent to all neurologists and neuropediatricians affiliated to the EAN practicing in Europe.
RESULTS
We have collected answers from 239 members based in 40 European member states. Even though most of the responders are aware on neurogenetic diseases, when we come to amenability of carrying out a complete genetic diagnosis, almost one third of the responders declare that are not happy with the current way of ordering genetic analyses in their Countries. Furthermore, while single gene analysis is diffusely present in Europe, whole exome and genome sequencing are not easily accessible, with considerable variabilities between Countries. Almost 10% of the responders didn't know if pre-symptomatic and prenatal diagnosis is available in their Countries, and 47,3% were not aware of which newborn screening programs are available. Finally, 96,3% of responders declare that there is a need for education and training in neurogenetics.
CONCLUSIONS
We believe that this survey may be of importance for all European stakeholders in neurogenetics in identifying key priorities, targeting areas to encourage education/travel fellowships and educational seminars in the future as this area will only accelerate and diagnostic requirements expand.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Bassetti, Claudio L.A. |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1468-1331 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Mar 2022 09:43 |
Last Modified: |
12 Mar 2023 00:25 |
Publisher DOI: |
10.1111/ene.15320 |
PubMed ID: |
35271759 |
Uncontrolled Keywords: |
Europe disease diagnosis neurogenetics rare diseases survey |
BORIS DOI: |
10.48350/167204 |
URI: |
https://boris.unibe.ch/id/eprint/167204 |
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