Scheuren, Paulina Simonne; Nauer, Natascha; Rosner, Jan; Curt, Armin; Hubli, Michèle (2022). Cold evoked potentials elicited by rapid cooling of the skin in young and elderly healthy individuals. Scientific reports, 12(1), p. 4137. Springer Nature 10.1038/s41598-022-07967-x
|
Text
s41598-022-07967-x.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
Cold-evoked potentials (CEPs) constitute a novel electrophysiological tool to assess cold-specific alterations in somatosensory function. As an important step towards the clinical implementation of CEPs as a diagnostic tool, we evaluated the feasibility and reliability of CEPs in response to rapid cooling of the skin (-300 °C/s) and different stimulation sites in young and elderly healthy individuals. Time-locked electroencephalographic responses were recorded from at vertex in fifteen young (20-40 years) and sixteen elderly (50-70 years), individuals in response to 15 rapid cold stimuli (-300 °C/s) applied to the skin of the hand dorsum, palm, and foot dorsum. High CEP proportions were shown for young individuals at all sites (hand dorsum/palm: 100% and foot: 79%) and elderly individuals after stimulation of the hand dorsum (81%) and palm (63%), but not the foot (44%). Depending on the age group and stimulation site, test-retest reliability was "poor" to "substantial" for N2P2 amplitudes and N2 latencies. Rapid cooling of the skin enables the recording of reliable CEPs in young individuals. In elderly individuals, CEP recordings were only robust after stimulation of the hand, but particularly challenging after stimulation of the foot. Further improvements in stimulation paradigms are warranted to introduce CEPs for clinical diagnostics.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Rosner, Jan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Mar 2022 12:19 |
Last Modified: |
05 Dec 2022 16:14 |
Publisher DOI: |
10.1038/s41598-022-07967-x |
PubMed ID: |
35264694 |
BORIS DOI: |
10.48350/167222 |
URI: |
https://boris.unibe.ch/id/eprint/167222 |
Actions (login required)
 |
Edit item |