Balmer, Lisa; Seth-Smith, Helena M B; Egli, Adrian; Casanova, Carlo; Kronenberg, Andreas Oskar; Schrenzel, Jacques; Marschall, Jonas; Sommerstein, Rami (2022). Agrobacterium species bacteraemia, Switzerland, 2008 to 2019: a molecular epidemiological study. Antimicrobial resistance and infection control, 11(1), p. 47. BioMed Central 10.1186/s13756-022-01086-y
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BACKGROUND
Agrobacterium spp. are infrequent agents of bloodstream infections linked to healthcare-associated outbreaks. However, it is unclear if outbreaks also occur across larger geographic areas. Triggered by two local clusters from putative point sources, our aim was to detect potential additional clusters in Switzerland.
METHODS
We performed a nationwide descriptive study of cases in Switzerland based on a prospective surveillance system (Swiss Centre for Antibiotic Resistance, anresis.ch), from 2008 to 2019. We identified patients with Agrobacterium spp. isolated from blood cultures and used a survey to collect clinical-epidemiological information and susceptibility testing results. We performed whole genome sequencing (WGS) of available clinical isolates and determined their relatedness by single nucleotide polymorphism (SNP) variant calling analysis.
RESULTS
We identified a total of 36 cases of Agrobacterium spp. from blood samples over 10 years. Beyond previously known local clusters, no new ones were identified. WGS-based typing was performed on 22 available isolates and showed no clonal relationships between newly identified isolates or to those from the known clusters, with all isolates outside these clusters being at least 50 SNPs apart.
CONCLUSION AND RELEVANCE
Agrobacterium spp. bacteraemia is infrequently detected and, given that it may be healthcare-associated and stem from a point source, occurrence of multiple episodes should entail an outbreak investigation. With the help of the national antimicrobial resistance surveillance system we identified multiple clinical cases of this rare pathogen but found no evidence by WGS that suggested a nation-wide outbreak.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology |
UniBE Contributor: |
Casanova, Carlo, Kronenberg, Andreas Oskar, Marschall, Jonas, Sommerstein, Rami |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
2047-2994 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Mar 2022 10:18 |
Last Modified: |
05 Dec 2022 16:14 |
Publisher DOI: |
10.1186/s13756-022-01086-y |
PubMed ID: |
35264215 |
Uncontrolled Keywords: |
Agrobacterium species Nosocomial Outbreak WGS |
BORIS DOI: |
10.48350/167226 |
URI: |
https://boris.unibe.ch/id/eprint/167226 |
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