Motor abnormalities are associated with poor social and functional outcomes in schizophrenia.

Nadesalingam, Niluja; Chapellier, Victoria; Lefebvre, Stephanie; Pavlidou, Anastasia; Stegmayer, Katharina; Alexaki, Danai; Baumann Gama, Daniel; Maderthaner, Lydia; von Känel, Sofie; Wüthrich, Florian; Walther, Sebastian (2022). Motor abnormalities are associated with poor social and functional outcomes in schizophrenia. Comprehensive psychiatry, 115, p. 152307. Elsevier 10.1016/j.comppsych.2022.152307

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BACKGROUND

Up to 50% of patients with schizophrenia are suffering from motor abnormalities, which may contribute to decreased quality of life, impaired work capacity, and a reduced life expectancy by 10-20 years. However, the effect of motor abnormalities on social and global functioning, as well as, functional capacity is not clear. We hypothesized, that the presence of motor abnormalities is associated with poorer functional outcomes in patients with schizophrenia.

METHODS

We collected data on 5 different motor abnormalities in 156 patients suffering from schizophrenia spectrum disorders: parkinsonism, catatonia, dyskinesia, neurological soft signs and psychomotor slowing (PS). Additionally, we used three different scales to evaluate the functional outcomes in these patients: the Global Assessment of Functioning (GAF) and the Social and Occupational Functioning Assessment Scale (SOFAS) which use clinicians' judgment; and one using a performance-based measure of functional capacity, the brief version of the UCSD Performance-based Skills Assessment (UPSA-B).

RESULTS

Our analysis demonstrated that patients with catatonia (all F > 4.5; p < 0.035) and parkinsonism (all F > 4.9; p < 0.027) scored lower on GAF and SOFAS compared to patients without catatonia and parkinsonism. In contrast, no significant difference on functional outcomes between patients with dyskinesia versus without dyskinesia exist in our study. Furthermore, there are statistically significant negative correlations for parkinsonism and PS with GAF, SOFAS and UPSA-B (all tau are at least -0.152, p-value <0.036). We also found significant negative correlations between catatonia and both GAF & SOFAS (all tau are at least -0.203, p-value<0.001) and between NES and SOFAS (tau = -0.137, p-value = 0.033).

CONCLUSION

Here, we showed that four of the most common motor abnormalities observed in schizophrenia were associated with at least one of the patients' functional outcomes. The stronger the motor impairment was the worse the global and social functioning. Future studies need to test, whether amelioration of motor abnormalities is linked to improved community functioning.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Nadesalingam, Niluja; Chapellier, Victoria Joséphine Bérengère Marie; Pavlidou, Anastasia; Stegmayer, Katharina Deborah Lena; Alexaki, Despoina Danai; Baumann Gama, Daniel Eduardo; Maderthaner, Lydia Verena; von Känel, Sofie Amanda; Wüthrich, Florian and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0010-440X

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

21 Mar 2022 09:57

Last Modified:

19 Apr 2022 00:14

Publisher DOI:

10.1016/j.comppsych.2022.152307

PubMed ID:

35303585

Uncontrolled Keywords:

Functional capacity Functional outcomes Global functioning Motor abnormalities Psychosis Schizophrenia

BORIS DOI:

10.48350/167640

URI:

https://boris.unibe.ch/id/eprint/167640

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