School-age structural and functional MRI and lung function in children following lung resection for congenital lung malformation in infancy.

Willers, Corin; Maager, Lukas; Bauman, Grzegorz; Cholewa, Dietmar; Stranzinger, Enno; Raio, Luigi; Casaulta, Carmen; Latzin, Philipp (2022). School-age structural and functional MRI and lung function in children following lung resection for congenital lung malformation in infancy. Pediatric radiology, 52(7), pp. 1255-1265. Springer-Verlag 10.1007/s00247-022-05317-7

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BACKGROUND

The management of asymptomatic congenital lung malformations is debated. Particularly, there is a lack of information regarding long-term growth and development of the remaining lung in children following lung resection for congenital lung malformations. In addition to conventional pulmonary function tests, we used novel functional magnetic resonance imaging (MRI) methods to measure perfusion and ventilation.

OBJECTIVE

To assess functionality of the remaining lung expanded into the thoracic cavity after resection of congenital lung malformations.

MATERIALS AND METHODS

A prospective, cross-sectional pilot study in five children who had surgery for congenital lung malformations during infancy. Participants had structural and functional MRI as well as spirometry, body plethysmography and multiple breath washout at school age.

RESULTS

Structural MRI showed an expansion of the remaining lung in all cases. Fractional ventilation and relative perfusion of the expanded lung were locally decreased in functional MRI. In all other parts of the lungs, fractional ventilation and relative perfusion were normal in all children. There was an association between overall impairment of perfusion and elevated lung clearance index. The results of spirometry and body plethysmography varied between patients, including normal lung function, restriction and obstruction.

CONCLUSION

Fractional ventilation and relative perfusion maps from functional MRI specifically locate impairment of the remaining lung after lung resection. These changes are not captured by conventional measures such as structural MRI and standard pulmonary function tests. Therefore, following lung resection for congenital lung malformation, children should be investigated more systematically with functional lung MRI.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Willers, Corin; Maager, Lukas; Cholewa, Dietmar; Stranzinger, Enno; Raio, Luigi; Casaulta, Carmen and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0301-0449

Publisher:

Springer-Verlag

Language:

English

Submitter:

Pubmed Import

Date Deposited:

21 Mar 2022 08:07

Last Modified:

15 Jun 2022 00:13

Publisher DOI:

10.1007/s00247-022-05317-7

PubMed ID:

35305121

Uncontrolled Keywords:

Children Congenital Infants Lung Magnetic resonance imaging Malformation Pulmonary Surgery

BORIS DOI:

10.48350/167659

URI:

https://boris.unibe.ch/id/eprint/167659

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