Emergence and global spread of Listeria monocytogenes main clinical clonal complex.

Moura, Alexandra; Lefrancq, Noémie; Wirth, Thierry; Leclercq, Alexandre; Borges, Vítor; Gilpin, Brent; Dallman, Timothy J; Frey, Joachim; Franz, Eelco; Nielsen, Eva M; Thomas, Juno; Pightling, Arthur; Howden, Benjamin P; Tarr, Cheryl L; Gerner-Smidt, Peter; Cauchemez, Simon; Salje, Henrik; Brisse, Sylvain; Lecuit, Marc (2021). Emergence and global spread of Listeria monocytogenes main clinical clonal complex. Science Advances, 7(49), eabj9805. American Association for the Advancement of Science 10.1126/sciadv.abj9805

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The bacterial foodborne pathogen Listeria monocytogenes clonal complex 1 (Lm-CC1) is the most prevalent clonal group associated with human listeriosis and is strongly associated with cattle and dairy products. Here, we analyze 2021 isolates collected from 40 countries, covering Lm-CC1 first isolation to present days, to define its evolutionary history and population dynamics. We show that Lm-CC1 spread worldwide from North America following the Industrial Revolution through two waves of expansion, coinciding with the transatlantic livestock trade in the second half of the 19th century and the rapid growth of cattle farming and food industrialization in the 20th century. In sharp contrast to its global spread over the past century, transmission chains are now mostly local, with limited inter- and intra-country spread. This study provides an unprecedented insight into L. monocytogenes phylogeography and population dynamics and highlights the importance of genome analyses for a better control of pathogen transmission.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Other Institutions > Emeriti, Vetsuisse Faculty
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Frey, Joachim

Subjects:

600 Technology > 630 Agriculture

ISSN:

2375-2548

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Barbara Bach

Date Deposited:

23 Mar 2022 09:19

Last Modified:

23 Mar 2022 09:19

Publisher DOI:

10.1126/sciadv.abj9805

PubMed ID:

34851675

BORIS DOI:

10.48350/167867

URI:

https://boris.unibe.ch/id/eprint/167867

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