GLP-1 Receptor Agonists and Coronary Arteries: From Mechanisms to Events.

Pahud de Mortanges, Aurélie; Sinaci, Eldem; Salvador Jr, Dante; Bally, Lia; Muka, Taulant; Wilhelm, Matthias; Bano, Arjola (2022). GLP-1 Receptor Agonists and Coronary Arteries: From Mechanisms to Events. Frontiers in Pharmacology, 13, p. 856111. Frontiers 10.3389/fphar.2022.856111

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Objective: Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) lower plasma glucose through effects on insulin and glucagon secretion and by decelerating gastric emptying. GLP-1 RAs have many beneficial effects beyond glycemic control, including a protective role on the cardiovascular system. However, underlying mechanisms linking GLP-1 RAs with coronary artery disease are complex and not fully elucidated. In this mini-review, we discuss these mechanisms and subsequent clinical events. Data Sources: We searched PubMed and Google Scholar for evidence on GLP-1 RAs and coronary events. We did not apply restrictions on article type. We reviewed publications for clinical relevance. Synopsis of Content: In the first part, we review the current evidence concerning the role of GLP-1 RAs on potential mechanisms underlying the development of coronary events. Specifically, we discuss the role of GLP-1 RAs on atherosclerosis and vasospasms of epicardial coronary arteries, as well as structural/functional changes of coronary microvasculature. In the second part, we summarize the clinical evidence on the impact of GLP-1 RAs in the prevention of acute and chronic coronary syndromes and coronary revascularization. We conclude by discussing existing gaps in the literature and proposing directions for future research.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Salvador, Dante Jr., Bally, Lia Claudia, Muka, Taulant, Wilhelm, Matthias, Bano, Arjola


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Pubmed Import

Date Deposited:

05 Apr 2022 12:24

Last Modified:

05 Dec 2022 16:18

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

GLP-1 receptor agonists acute and chronic coronary syndromes atherosclerosis coronary artery disease coronary microcirculation diabetes




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