Rodriguez, Belén; Larsson, Lars; Z'Graggen, Werner J (2022). Critical Illness Myopathy: Diagnostic Approach and Resulting Therapeutic Implications. Current treatment options in neurology, 24(4), pp. 173-182. Springer 10.1007/s11940-022-00714-7
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Purpose of review
Critical illness myopathy (CIM) is a common neuro-muscular complication of intensive care treatment associated with increased morbidity and mortality. The current guidelines for diagnosis include clinical and electrophysiological criteria as well as a muscle biopsy, and allow diagnosis only at an advanced stage of the disease. To date, there is no treatment for CIM available, apart from symptomatic and rehabilitative interventions. In this review, we discuss different diagnostic approaches and describe new treatment possibilities for CIM.
Recent findings
Of the diagnostic approaches evaluated, a new electrophysiological technique for measuring muscle excitability has the greatest potential to allow earlier diagnosis of CIM than the current guidelines do and thereby may facilitate the conduction of future pathophysiological and therapeutic studies. Although clinical trials are still lacking, in animal models, BGP-15, vamorolone, and ruxolitinib have been shown to have anti-inflammatory effects, to reduce muscle wasting and to improve muscle function and survival.
Summary
In recent years, promising methods for early and confirmatory diagnosis of CIM have been developed, but still need validation. Experimental studies on novel pharmacological interventions show promising results in terms of preventive CIM treatments, but future clinical studies will be needed to study the effectiveness and safety of these drugs.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Rodriguez Galdin, Belén, Z'Graggen, Werner Josef |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1092-8480 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
05 Apr 2022 14:42 |
Last Modified: |
05 Dec 2022 16:18 |
Publisher DOI: |
10.1007/s11940-022-00714-7 |
PubMed ID: |
35370393 |
Uncontrolled Keywords: |
Electromyography Electrophysiology ICU–acquired weakness Intensive care unit Muscle velocity recovery cycles Myosin:actin ratio |
BORIS DOI: |
10.48350/169014 |
URI: |
https://boris.unibe.ch/id/eprint/169014 |
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