Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial.

Räber, Lorenz; Ueki, Yasushi; Otsuka, Tatsuhiko; Losdat, Sylvain; Häner, Jonas D; Lonborg, Jacob; Fahrni, Gregor; Iglesias, Juan F; van Geuns, Robert-Jan; Ondracek, Anna S; Radu Juul Jensen, Maria D; Zanchin, Christian; Stortecky, Stefan; Spirk, David; Siontis, George C; Saleh, Lanja; Matter, Christian M; Daemen, Joost; Mach, François; Heg, Dik; ... (2022). Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial. JAMA - the journal of the American Medical Association, 327(18), pp. 1771-1781. American Medical Association 10.1001/jama.2022.5218

[img] Text
R_ber_JAMA_2022.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (886kB) | Request a copy

Importance

Coronary plaques that are prone to rupture and cause adverse cardiac events are characterized by large plaque burden, large lipid content, and thin fibrous caps. Statins can halt the progression of coronary atherosclerosis; however, the effect of the proprotein convertase subtilisin kexin type 9 inhibitor alirocumab added to statin therapy on plaque burden and composition remains largely unknown.

Objective

To determine the effects of alirocumab on coronary atherosclerosis using serial multimodality intracoronary imaging in patients with acute myocardial infarction.

Design, Setting, and Participants

The PACMAN-AMI double-blind, placebo-controlled, randomized clinical trial (enrollment: May 9, 2017, through October 7, 2020; final follow-up: October 13, 2021) enrolled 300 patients undergoing percutaneous coronary intervention for acute myocardial infarction at 9 academic European hospitals.

Interventions

Patients were randomized to receive biweekly subcutaneous alirocumab (150 mg; n = 148) or placebo (n = 152), initiated less than 24 hours after urgent percutaneous coronary intervention of the culprit lesion, for 52 weeks in addition to high-intensity statin therapy (rosuvastatin, 20 mg).

Main Outcomes and Measures

Intravascular ultrasonography (IVUS), near-infrared spectroscopy, and optical coherence tomography were serially performed in the 2 non-infarct-related coronary arteries at baseline and after 52 weeks. The primary efficacy end point was the change in IVUS-derived percent atheroma volume from baseline to week 52. Two powered secondary end points were changes in near-infrared spectroscopy-derived maximum lipid core burden index within 4 mm (higher values indicating greater lipid content) and optical coherence tomography-derived minimal fibrous cap thickness (smaller values indicating thin-capped, vulnerable plaques) from baseline to week 52.

Results

Among 300 randomized patients (mean [SD] age, 58.5 [9.7] years; 56 [18.7%] women; mean [SD] low-density lipoprotein cholesterol level, 152.4 [33.8] mg/dL), 265 (88.3%) underwent serial IVUS imaging in 537 arteries. At 52 weeks, mean change in percent atheroma volume was -2.13% with alirocumab vs -0.92% with placebo (difference, -1.21% [95% CI, -1.78% to -0.65%], P < .001). Mean change in maximum lipid core burden index within 4 mm was -79.42 with alirocumab vs -37.60 with placebo (difference, -41.24 [95% CI, -70.71 to -11.77]; P = .006). Mean change in minimal fibrous cap thickness was 62.67 μm with alirocumab vs 33.19 μm with placebo (difference, 29.65 μm [95% CI, 11.75-47.55]; P = .001). Adverse events occurred in 70.7% of patients treated with alirocumab vs 72.8% of patients receiving placebo.

Conclusions and Relevance

Among patients with acute myocardial infarction, the addition of subcutaneous biweekly alirocumab, compared with placebo, to high-intensity statin therapy resulted in significantly greater coronary plaque regression in non-infarct-related arteries after 52 weeks. Further research is needed to understand whether alirocumab improves clinical outcomes in this population.

Trial Registration

ClinicalTrials.gov Identifier: NCT03067844.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Räber, Lorenz; Ueki, Yasushi; Otsuka, Tatsuhiko; Losdat, Sylvain Pierre; Häner, Jonas; Zanchin, Christian; Stortecky, Stefan; Spirk, David; Siontis, Georgios; Heg, Dierik Hans; Windecker, Stephan and Koskinas, Konstantinos

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0098-7484

Publisher:

American Medical Association

Language:

English

Submitter:

Pubmed Import

Date Deposited:

05 Apr 2022 14:14

Last Modified:

12 May 2022 12:29

Publisher DOI:

10.1001/jama.2022.5218

PubMed ID:

35368058

BORIS DOI:

10.48350/169023

URI:

https://boris.unibe.ch/id/eprint/169023

Actions (login required)

Edit item Edit item
Provide Feedback