Electrical Stimulation for Cerebral Vasospasm After Subarachnoid Hemorrhage: A Systematic Review.

Schlaeppi, Janine-Ai; Affentranger, Lucas; Bervini, David; Z'Graggen, Werner J.; Raabe, Andreas; Pollo, Claudio (2022). Electrical Stimulation for Cerebral Vasospasm After Subarachnoid Hemorrhage: A Systematic Review. Neuromodulation: technology at the neural interface, 25(8), pp. 1227-1239. Elsevier 10.1016/j.neurom.2022.01.020

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OBJECTIVES

Cerebral vasospasm is a severe and potentially lethal complication in patients with subarachnoid hemorrhage (SAH). Its pathogenesis is still not completely understood. The efficacy of current treatments, such as triple-H therapy or calcium channel blockers, is unsatisfactory, and a new therapy model would therefore be valuable. Electrical stimulation may have a considerable influence on cerebrovascular innervation. This systematic review gives an overview of the studies that have applied electrical stimulation in models of cerebral vasospasm.

MATERIALS AND METHODS

We performed a systematic review of the literature, searching PubMed and Ovid Embase with the keywords "electric stimulation," "cerebral vasospasm," "subarachnoid hemorrhage," "sympathetic," and "parasympathetic." Additional papers were identified from the reference lists of the articles identified in the literature search.

RESULTS

Increased cerebral blood flow (CBF) is a widely observed effect of spinal cord stimulation and sphenopalatine ganglion stimulation in models of physiological conditions or experimental cerebral vasospasm. Most studies were conducted in animals, 15 under physiological conditions and 11 in animals with SAH. Eight studies in humans were identified that examined the stimulation effect on CBF under physiological conditions. Only two studies looked at patients after SAH: one applied spinal cord stimulation (SCS) and the other transcutaneous electrical neurostimulation. Different mechanisms leading to stimulation-induced CBF increase that were discussed included "reversible functional sympathectomy," activation of brainstem vasomotor centers, involvement of central ascending pathways, release of neurohumoral factors, and interaction with sympathetic, parasympathetic, and trigeminal innervation. The results indicate that electrical stimulation is a promising procedure for prevention and treatment of cerebral vasospasm.

CONCLUSION

Electrical stimulation, especially SCS and sphenopalatine ganglion stimulation, is a promising adjunct for existing therapies for vasospasm after SAH. Further experiments and prospective clinical studies are needed to establish its potential usefulness as a therapy or prevention option.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Schläppi, Janine Ai, Bervini, David, Z'Graggen, Werner Josef, Raabe, Andreas, Pollo, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1094-7159

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

07 Apr 2022 09:58

Last Modified:

07 Dec 2022 00:11

Publisher DOI:

10.1016/j.neurom.2022.01.020

PubMed ID:

35382977

Uncontrolled Keywords:

Cerebral blood flow cerebral vasospasm electric stimulation sphenopalatine ganglion stimulation spinal cord stimulation

BORIS DOI:

10.48350/169098

URI:

https://boris.unibe.ch/id/eprint/169098

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