Hirzel, Cédric; Projer, Lea; Atkinson, Andrew; Surial, Bernard; Mueller, Nicolas J; Manuel, Oriol; Mombelli, Matteo; van Delden, Christian; Hirsch, Hans H; Boggian, Katia; Walti, Laura N; Sidler, Daniel; Hadaya, Karine; Dickenmann, Michael; Müller, Thomas F; Binet, Isabelle; Golshayan, Déla; Huynh-Do, Uyen (2022). Infection Risk in the First Year After ABO-incompatible Kidney Transplantation: A Nationwide Prospective Cohort Study. Transplantation, 106(9), pp. 1875-1883. Wolters Kluwer Health 10.1097/TP.0000000000004109
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BACKGROUND
ABO-incompatible (ABOi) kidney transplantation (KT) expands the kidney donor pool and may help to overcome organ shortage. Nonetheless, concerns about infectious complications associated with ABOi-KT have been raised.
METHODS
In a nationwide cohort (Swiss Transplant Cohort Study), we compared the risk for infectious complications among ABOi and ABO-compatible (ABOc) renal transplant recipients. Infections needed to fulfill rigorous, prespecified criteria to be classified as clinically relevant. Unadjusted and adjusted competing risk regression models were used to compare the time to the first clinically relevant infection among ABOi-KT and ABOc-KT recipients. Inverse probability weighted generalized mixed-effects Poisson regression was used to estimate incidence rate ratios for infection.
RESULTS
We included 757 living-donor KT recipients (639 ABOc; 118 ABOi) and identified 717 infection episodes. The spectrum of causative pathogens and the anatomical sites affected by infections were similar between ABOi-KT and ABOc-KT recipients. There was no significant difference in time to first posttransplant infection between ABOi-KT and ABOc-KT recipients (subhazard ratio, 1.24; 95% confidence interval [CI], 0.93-1.66; P = 0.142). At 1 y, the crude infection rate was 1.11 (95% CI, 0.93-1.33) episodes per patient-year for ABOi patients and 0.94 (95% CI, 0.86-1.01) for ABOc-KT recipients. Inverse probability weighted infection rates were similar between groups (adjusted incidence rate ratio, 1.12; 95% CI, 0.83-1.52; P = 0.461).
CONCLUSIONS
The burden of infections during the first year posttransplant was high but not relevantly different in ABOi-KT and ABOc-KT recipients. Our results highlight that concerns regarding infectious complications should not affect the implementation of ABOi-KT programs.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Hirzel, Cédric, Atkinson, Andrew David, Surial, Bernard, Walti, Laura Naëmi, Sidler, Daniel (A), Huynh-Do, Uyen |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1534-6080 |
Publisher: |
Wolters Kluwer Health |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 Apr 2022 09:58 |
Last Modified: |
29 Mar 2023 23:38 |
Publisher DOI: |
10.1097/TP.0000000000004109 |
PubMed ID: |
35389968 |
BORIS DOI: |
10.48350/169146 |
URI: |
https://boris.unibe.ch/id/eprint/169146 |
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