Role of Adjuvant Radiotherapy in Non-Small Cell Lung Cancer-A Review.

Süveg, Krisztian; Plasswilm, Ludwig; Iseli, Thomas; Leskow, Pawel; Fischer, Galina Farina; Putora, Paul Martin (2022). Role of Adjuvant Radiotherapy in Non-Small Cell Lung Cancer-A Review. Cancers, 14(7) MDPI AG 10.3390/cancers14071617

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BACKGROUND

For patients with completely resected non-small cell lung cancer (NSCLC) with ipsilateral mediastinal lymph node involvement (pN2), the administration of adjuvant chemotherapy is the standard of care. The role of postoperative radiation therapy (PORT) is controversial.

METHODS

We describe the current literature focusing on the role of PORT in completely resected NSCLC patients with pN2 involvement and reflect on its role in current guidelines.

RESULTS

Based on the results of the recent Lung ART and PORT-C trials, the authors conclude that PORT cannot be generally recommended for all resected pN2 NSCLC patients. A substantial decrease in the locoregional relapse rate without translating into a survival benefit suggests that some patients with risk factors might benefit from PORT. This must be balanced against the risk of cardiopulmonary toxicity with potentially associated mortality. Lung ART has already changed the decision making for the use of PORT in daily practice for many European lung cancer experts, with lower rates of recommendations for PORT overall.

CONCLUSIONS

PORT is still used, albeit decreasingly, for completely resected NSCLC with pN2 involvement. High-level evidence for its routine use is lacking. Further analyses are required to identify patients who would potentially benefit from PORT.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Plasswilm, Ludwig and Putora, Paul Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2072-6694

Publisher:

MDPI AG

Language:

English

Submitter:

Pubmed Import

Date Deposited:

13 Apr 2022 13:31

Last Modified:

13 Apr 2022 13:40

Publisher DOI:

10.3390/cancers14071617

PubMed ID:

35406388

Uncontrolled Keywords:

NSCLC PORT radiation therapy resection risk factors

BORIS DOI:

10.48350/169289

URI:

https://boris.unibe.ch/id/eprint/169289

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