Dhana, Klodian; Franco, Oscar H; Ritz, Ethan M; Ford, Christopher N; Desai, Pankaja; Krueger, Kristin R; Holland, Thomas M; Dhana, Anisa; Liu, Xiaoran; Aggarwal, Neelum T; Evans, Denis A; Rajan, Kumar B (2022). Healthy lifestyle and life expectancy with and without Alzheimer's dementia: population based cohort study. BMJ, 377, e068390. BMJ Publishing Group 10.1136/bmj-2021-068390
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OBJECTIVE
To determine the impact of lifestyle factors on life expectancy lived with and without Alzheimer's dementia.
DESIGN
Prospective cohort study.
SETTING
The Chicago Health and Aging Project, a population based cohort study in the United States.
PARTICIPANTS
2449 men and women aged 65 years and older.
MAIN EXPOSURE
A healthy lifestyle score was developed based on five modifiable lifestyle factors: a diet for brain health (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay-MIND diet score in upper 40% of cohort distribution), late life cognitive activities (composite score in upper 40%), moderate or vigorous physical activity (≥150 min/week), no smoking, and light to moderate alcohol consumption (women 1-15 g/day; men 1-30 g/day).
MAIN OUTCOME
Life expectancy with and without Alzheimer's dementia in women and men.
RESULTS
Women aged 65 with four or five healthy factors had a life expectancy of 24.2 years (95% confidence interval 22.8 to 25.5) and lived 3.1 years longer than women aged 65 with zero or one healthy factor (life expectancy 21.1 years, 19.5 to 22.4). Of the total life expectancy at age 65, women with four or five healthy factors spent 10.8% (2.6 years, 2.0 to 3.3) of their remaining years with Alzheimer's dementia, whereas women with zero or one healthy factor spent 19.3% (4.1 years, 3.2 to 5.1) with the disease. Life expectancy for women aged 65 without Alzheimer's dementia and four or five healthy factors was 21.5 years (20.0 to 22.7), and for those with zero or one healthy factor it was 17.0 years (15.5 to 18.3). Men aged 65 with four or five healthy factors had a total life expectancy of 23.1 years (21.4 to 25.6), which is 5.7 years longer than men aged 65 with zero or one healthy factor (life expectancy 17.4 years, 15.8 to 20.1). Of the total life expectancy at age 65, men with four or five healthy factors spent 6.1% (1.4 years, 0.3 to 2.0) of their remaining years with Alzheimer's dementia, and those with zero or one healthy factor spent 12.0% (2.1 years, 0.2 to 3.0) with the disease. Life expectancy for men aged 65 without Alzheimer's dementia and four or five healthy factors was 21.7 years (19.7 to 24.9), and for those with zero or one healthy factor life expectancy was 15.3 years (13.4 to 19.1).
CONCLUSION
A healthy lifestyle was associated with a longer life expectancy among men and women, and they lived a larger proportion of their remaining years without Alzheimer's dementia. The life expectancy estimates might help health professionals, policy makers, and stakeholders to plan future healthcare services, costs, and needs.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Franco Duran, Oscar Horacio |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1756-1833 |
Publisher: |
BMJ Publishing Group |
Funders: |
[215] National Institute of Health (NIH) |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Apr 2022 17:20 |
Last Modified: |
05 Dec 2022 16:18 |
Publisher DOI: |
10.1136/bmj-2021-068390 |
PubMed ID: |
35418416 |
BORIS DOI: |
10.48350/169332 |
URI: |
https://boris.unibe.ch/id/eprint/169332 |
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