Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation.

Coughlan, John Joseph; Maeng, Michael; Räber, Lorenz; Brugaletta, Salvatore; Aytekin, Alp; Okkels Jensen, Lisette; Bär, Sarah; Ortega-Paz, Luis; Laugwitz, Karl-Ludwig; Madsen, Morten; Heg, Dik; Sabaté, Manel; Kufner, Sebastian; Warnakula Olesen, Kevin Kris; Kastrati, Adnan; Windecker, Stephan; Cassese, Salvatore (2022). Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation. Revista española de cardiología (English ed.), 75(11), pp. 894-902. Elsevier 10.1016/j.rec.2022.02.003

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INTRODUCTION AND OBJECTIVES

The DECADE cooperation is a pooled analysis of individual patient data from drug-eluting stent (DES) trials with a 10-year follow-up. This analysis reports the risk of definite stent thrombosis (ST) through to 10 years after percutaneous coronary intervention (PCI) in patients treated with early- and new-generation DES.

METHODS

Individual patient data from 5 DES trials with a 10-year follow-up were pooled. The primary endpoint was definite ST up to 10 years after PCI. Patients were divided into 2 groups as per the generation of DES implanted (early and new DES). Individual participant data were analyzed using a 1-stage approach.

RESULTS

We included 9700 patients, 6866 in the new DES group and 2834 in the early DES group. Through to 10 years, definite ST occurred in 69 of 6866 patients treated with new DES and in 91 of 2834 patients treated with early DES (1.0% vs 3.5%, adjusted hazard ratio, 0.32; 95%CI, 0.23-0.45). The rate of definite ST was lower in the new DES group than in the early DES group from 1 to 5 years (rate ratio, 0.14; 95%CI, 0.08-0.26) and from 5 to 10 years (rate ratio, 0.23; 95%CI, 0.08-0.61) after PCI.

CONCLUSIONS

The incidence of definite ST through to 10 years after PCI with new-generation DES was 1%. New-generation DES are associated with a lower 10-year incidence of definite ST than early-generation DES, particularly beyond 1 year after PCI.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Räber, Lorenz, Bär, Sarah, Heg, Dierik Hans, Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1885-5857

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

20 Apr 2022 10:29

Last Modified:

20 Feb 2024 14:15

Publisher DOI:

10.1016/j.rec.2022.02.003

PubMed ID:

35437213

Uncontrolled Keywords:

Drug-eluting stents Intervención coronaria percutánea Percutaneous coronary intervention Stent thrombosis Stents liberadores de fármacos Trombosis del stent

BORIS DOI:

10.48350/169392

URI:

https://boris.unibe.ch/id/eprint/169392

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