Decision making and surgical modality selection in glioblastoma patients: an international multicenter survey.

Gerritsen, Jasper K W; Broekman, Marike L D; De Vleeschouwer, Steven; Schucht, Philippe; Jungk, Christine; Krieg, Sandro M; Nahed, Brian V; Berger, Mitchel S; Vincent, Arnaud J P E (2022). Decision making and surgical modality selection in glioblastoma patients: an international multicenter survey. Journal of neuro-oncology, 156(3), pp. 465-482. Springer 10.1007/s11060-021-03894-5

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PURPOSE

Due to the lack of consensus on the management of glioblastoma patients, there exists variability amongst surgeons and centers regarding treatment decisions. Though, objective data about the extent of this heterogeneity is still lacking. We aim to evaluate and analyze the similarities and differences in neurosurgical practice patterns.

METHODS

The survey was distributed to members of the neurosurgical societies of the Netherlands (NVVN), Europe (EANS), the United Kingdom (SBNS) and the United States (CNS) between January and March 2021 with questions about the selection of surgical modality and decision making in glioblastoma patients.

RESULTS

Survey respondents (224 neurosurgeons) were from 41 countries. Overall, the most notable differences observed were the presence and timing of a multidisciplinary tumor board; the importance and role of various perioperative factors in the decision-making process, and the preferred treatment in various glioblastoma cases and case variants. Tumor boards were more common at academic centers. The intended extent of resection for glioblastoma resections in eloquent areas was limited more often in European neurosurgeons. We found a strong relationship between the surgeon's theoretical survey answers and their actual approach in presented patient cases. In general, the factors which were found to be theoretically the most important in surgical decision making were confirmed to influence the respondents' decisions to the greatest extent in practice as well.

DISCUSSION

This survey illustrates the theoretical and practical heterogeneity among surgeons and centers in their decision making and treatment selection for glioblastoma patients. These data invite further evaluations to identify key variables that can be optimized and may therefore benefit from consensus.

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