Saxenhofer, Moritz; Labutin, Anton; White, Thomas A.; Heckel, Gerald (2022). Host genetic factors associated with the range limit of a European hantavirus. Molecular Ecology, 31(1), pp. 252-265. Wiley-Blackwell 10.1111/mec.16211
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Molecular_Ecology_-_2021_-_Saxenhofer_-_Host_genetic_factors_associated_with_the_range_limit_of_a_European_hantavirus.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
The natural host ranges of many viruses are restricted to very specific taxa. Little is
known about the molecular barriers between species that lead to the establishment
of this restriction or generally prevent virus emergence in new hosts. Here, we identify
genomic polymorphisms in a natural rodent host associated with a strong genetic
barrier to the transmission of European Tula orthohantavirus (TULV). We analysed the
very abrupt spatial transition between two major phylogenetic clades in TULV across
the comparatively much wider natural hybrid zone between evolutionary lineages of
their reservoir host, the common vole (Microtus arvalis). Genomic scans of 79,225 single
nucleotide polymorphisms (SNPs) in 323 TULV-infected host individuals detected 30 SNPs that were consistently associated with the TULV clades CEN.S or EST.S in two replicate sampling transects. Focusing the analysis on 199 voles with evidence of genomic admixture at the individual level (0.1–0.9) supported statistical significance for all 30 loci. Host genomic variation at these SNPs explained up to 37.6% of clade-specific TULV infections. Genes in the vicinity of associated SNPs include SAHH, ITCH and two members of the Syngr gene family, which are involved in functions related to immune response or membrane transport. This study demonstrates the relevance of natural hybrid zones as systems not only for studying processes of evolutionary divergence and speciation, but also for the detection of evolving genetic barriers for specialized parasites.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) 08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) > Population Genetics |
UniBE Contributor: |
Saxenhofer, Moritz, Labutin, Anton, Heckel, Gerald |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
0962-1083 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Susanne Holenstein |
Date Deposited: |
27 Apr 2022 12:07 |
Last Modified: |
23 Dec 2022 09:32 |
Publisher DOI: |
10.1111/mec.16211 |
PubMed ID: |
34614264 |
BORIS DOI: |
10.48350/169457 |
URI: |
https://boris.unibe.ch/id/eprint/169457 |
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