Konstantinoudis, Garyfallos; Minelli, Cosetta; Vicedo-Cabrera, Ana Maria; Ballester, Joan; Gasparrini, Antonio; Blangiardo, Marta (2022). Ambient heat exposure and COPD hospitalisations in England: a nationwide case-crossover study during 2007-2018. Thorax, 77(11), pp. 1098-1104. BMJ Publishing Group 10.1136/thoraxjnl-2021-218374
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BACKGROUND
There is emerging evidence suggesting a link between ambient heat exposure and chronic obstructive pulmonary disease (COPD) hospitalisations. Individual and contextual characteristics can affect population vulnerabilities to COPD hospitalisation due to heat exposure. This study quantifies the effect of ambient heat on COPD hospitalisations and examines population vulnerabilities by age, sex and contextual characteristics.
METHODS
Individual data on COPD hospitalisation at high geographical resolution (postcodes) during 2007-2018 in England was retrieved from the small area health statistics unit. Maximum temperature at 1 km ×1 km resolution was available from the UK Met Office. We employed a case-crossover study design and fitted Bayesian conditional Poisson regression models. We adjusted for relative humidity and national holidays, and examined effect modification by age, sex, green space, average temperature, deprivation and urbanicity.
RESULTS
After accounting for confounding, we found 1.47% (95% Credible Interval (CrI) 1.19% to 1.73%) increase in the hospitalisation risk for every 1°C increase in temperatures above 23.2°C (lags 0-2 days). We reported weak evidence of an effect modification by sex and age. We found a strong spatial determinant of the COPD hospitalisation risk due to heat exposure, which was alleviated when we accounted for contextual characteristics. 1851 (95% CrI 1 576 to 2 079) COPD hospitalisations were associated with temperatures above 23.2°C annually.
CONCLUSION
Our study suggests that resources should be allocated to support the public health systems, for instance, through developing or expanding heat-health alerts, to challenge the increasing future heat-related COPD hospitalisation burden.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) 10 Strategic Research Centers > Oeschger Centre for Climate Change Research (OCCR) |
UniBE Contributor: |
Vicedo Cabrera, Ana Maria |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0040-6376 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
25 Apr 2022 15:26 |
Last Modified: |
05 Dec 2022 16:19 |
Publisher DOI: |
10.1136/thoraxjnl-2021-218374 |
PubMed ID: |
35459745 |
Uncontrolled Keywords: |
COPD Exacerbations COPD epidemiology COPD exacerbations mechanisms |
BORIS DOI: |
10.48350/169483 |
URI: |
https://boris.unibe.ch/id/eprint/169483 |
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